{"id":"W4200597408","doi":"10.1177/13524585211061335","title":"Autoimmunity and long-term safety and efficacy of alemtuzumab for multiple sclerosis: Benefit/risk following review of trial and post-marketing data","year":2021,"lang":"en","type":"review","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"bluebird bio; Wellcome Trust; National Institute for Health and Care Research; Sanofi","keywords":"Alemtuzumab; Autoimmunity; Multiple sclerosis; Medicine; Immunology; Adverse effect; Autoimmune disease; Disease; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01113597,0.0011433,0.007582927,0.0006065688,0.001020815,0.0002006458,0.0009176097,0.0005454941,0.00005322392],"category_scores_gemma":[0.04981194,0.0009154828,0.001538913,0.0006483453,0.0006524954,0.0003939927,0.002515174,0.001943318,8.494792e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002594345,"about_ca_system_score_gemma":0.0007947906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001348196,"about_ca_topic_score_gemma":0.00007430321,"domain_scores_codex":[0.9903088,0.001819599,0.004083627,0.001413425,0.001355721,0.001018821],"domain_scores_gemma":[0.9804047,0.01238942,0.003305481,0.001960901,0.001208235,0.0007312316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.005005968,0.000486487,0.005322464,0.1083281,0.003135042,0.00001083661,0.0001414787,4.688928e-7,0.0002413531,6.470165e-7,0.0001876145,0.8771396],"study_design_scores_gemma":[0.07905239,0.001234268,0.1831672,0.7032095,0.01111632,0.0002561427,0.0002163468,0.0002676774,0.0000209525,7.377424e-7,0.02044908,0.00100939],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03625503,0.954207,0.00008043657,0.0001488861,0.0004174752,0.005989889,0.002855516,0.00003672563,0.00000902836],"genre_scores_gemma":[0.004917475,0.9888204,0.004451402,0.00005630476,0.0004626961,0.0001493729,0.0009319985,0.0001856391,0.00002465444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8761302,"threshold_uncertainty_score":0.9993296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2312901325548926,"score_gpt":0.3909515843284551,"score_spread":0.1596614517735625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}