{"id":"W4200604587","doi":"10.1186/s13072-021-00429-0","title":"The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"GlaxoSmithKline; Canadian Cancer Society; Hospital for Sick Children; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; McGill University","keywords":"DNA methylation; DNMT1; Biology; Decitabine; Epigenetics; Methylation; DNA demethylation; Bisulfite sequencing; Reprogramming; Embryonic stem cell; Demethylation; Molecular biology; DNA methyltransferase; Azacitidine; CpG site; Downregulation and upregulation; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002284594,0.0006095286,0.0003948032,0.0003538653,0.0001410748,0.0002403333,0.0003042717,0.000297261,0.00148207],"category_scores_gemma":[0.0001096182,0.0002147532,0.0003958892,0.000195104,0.0001965873,0.0001572879,0.0002396869,0.0006503285,0.0005651194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886648,"about_ca_system_score_gemma":0.0003028394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004508733,"about_ca_topic_score_gemma":0.001203989,"domain_scores_codex":[0.9998102,0.00002709542,0.00002691106,0.00004215699,0.00006198158,0.00003174317],"domain_scores_gemma":[0.9999014,0.00001513812,0.00003366918,0.00001874614,0.0000122248,0.00001879368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000708811,0.00002451904,0.0001062508,0.00006223615,0.000008731226,0.00001934567,0.000006881438,0.0001218052,0.9980142,0.0000488092,0.0000724909,0.001443821],"study_design_scores_gemma":[0.00001836649,0.0002796676,0.0009198375,0.000005763658,0.00001558323,0.00005692081,0.000004454226,0.0003841054,0.9967932,0.00001377342,0.001506411,0.00000190161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782406,0.005438861,0.008321706,0.0001940286,0.00007618777,0.0002005478,0.001901482,0.0005284224,0.005098213],"genre_scores_gemma":[0.9864962,0.002068926,0.006024026,0.00006201067,0.00001499336,0.0001519814,0.00175342,0.00004822906,0.00338028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148207,"threshold_uncertainty_score":0.004958034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008862220160701558,"score_gpt":0.2488402461569788,"score_spread":0.2399780259962772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}