{"id":"W4200605356","doi":"10.1002/ajh.26434","title":"Efficacy and tolerability of <scp>once‐weekly</scp> selinexor, bortezomib, and dexamethasone in comparison with standard <scp>twice‐weekly</scp> bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the <scp>BOSTON</scp> study","year":2021,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation","funders":"Karyopharm Therapeutics","keywords":"Medicine; Bortezomib; Dexamethasone; Multiple myeloma; Internal medicine; Population; Pharmacology; Nephrotoxicity; Renal function; Tolerability; Oncology; Kidney; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001917636,0.001014293,0.003037614,0.0005389721,0.000294512,0.00104951,0.0005650042,0.0008785764,0.002516663],"category_scores_gemma":[0.001399942,0.0004372289,0.006813624,0.0008192499,0.0004289749,0.0009255215,0.0004128656,0.001477671,0.0004481609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009198266,"about_ca_system_score_gemma":0.0006491829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036841,"about_ca_topic_score_gemma":0.002796954,"domain_scores_codex":[0.9991938,0.0002559732,0.0001278193,0.0001837516,0.0001286574,0.0001099305],"domain_scores_gemma":[0.9986798,0.0002651119,0.0004628134,0.000144877,0.0001020119,0.0003453814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8025128,0.002972062,0.1140316,0.00142421,0.02626311,0.0002375971,0.0002086843,0.001942477,0.007603575,0.0001001257,0.002207176,0.04049651],"study_design_scores_gemma":[0.1914134,0.1642489,0.5934325,0.00031,0.03776886,0.0008125218,0.0003650786,0.002911739,0.002760749,0.0007275207,0.005011546,0.000237093],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987069,0.009505021,0.0001463299,0.0001581079,0.00005583362,0.0002550222,0.002068689,0.00001863576,0.0007232664],"genre_scores_gemma":[0.9934719,0.002028992,0.0001721168,0.0002016393,0.0001248532,0.0002433786,0.003173474,0.00001581961,0.0005679765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003037614,"threshold_uncertainty_score":0.01014149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931272400488909,"score_gpt":0.2923203198681854,"score_spread":0.2730075958632963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}