{"id":"W4200612476","doi":"10.1016/j.celrep.2021.110078","title":"FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Université Laval; Hospital for Sick Children","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Hereditary Disease Foundation; Muscular Dystrophy Canada; National Center of Neurology and Psychiatry; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Nuclease; DNA; Mechanism (biology); Genetics; Biology; Genome instability; Tandem repeat; Cell biology; DNA damage; Genome; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002164816,0.0002168688,0.0002272945,0.00003552637,0.00009720907,0.00002242384,0.00008967712,0.000124196,0.00005827602],"category_scores_gemma":[0.0004988533,0.0002307492,0.0001829035,0.0001246802,0.00005507724,0.000003430903,0.0002060401,0.00009390981,0.000003362602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003419378,"about_ca_system_score_gemma":0.0002891052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000135486,"about_ca_topic_score_gemma":0.00002910318,"domain_scores_codex":[0.9980623,0.00009471807,0.0005155662,0.000759223,0.0002854324,0.0002827587],"domain_scores_gemma":[0.9985013,0.00001429889,0.0003018387,0.0008271774,0.0001685013,0.0001868909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009108384,0.0004269196,0.002340895,0.00005660423,0.00003210818,0.0006915829,0.00004471295,0.00003516013,0.9952697,0.00001840489,0.0003609117,0.0006319044],"study_design_scores_gemma":[0.0003517561,0.0001336549,0.03014246,0.00003777939,0.0000388879,0.00003640894,0.00008033262,0.00001156582,0.9640861,0.0002637559,0.004562943,0.0002544032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947036,0.000280252,0.00005376436,0.00007748816,0.0003176898,0.0002048703,0.00003410884,0.00001933249,0.004308884],"genre_scores_gemma":[0.9977184,0.000273293,0.0001834168,0.0004186529,0.00001623314,0.00001356159,0.0003193896,0.00003911574,0.001017918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03118366,"threshold_uncertainty_score":0.9409679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141465288060936,"score_gpt":0.2162961832553772,"score_spread":0.2048815303747679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}