{"id":"W4200612476","doi":"10.1016/j.celrep.2021.110078","title":"FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Université Laval; Hospital for Sick Children","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Hereditary Disease Foundation; Muscular Dystrophy Canada; National Center of Neurology and Psychiatry; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Nuclease; DNA; Mechanism (biology); Genetics; Biology; Genome instability; Tandem repeat; Cell biology; DNA damage; Genome; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385044,0.0003765304,0.0002062678,0.0001765647,0.0001789037,0.0002405486,0.0002680616,0.0002865837,0.001285958],"category_scores_gemma":[0.0001795889,0.0001726061,0.00016807,0.00006539444,0.000266607,0.000310385,0.0001990411,0.0003395806,0.0003544103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274819,"about_ca_system_score_gemma":0.0001507809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002314751,"about_ca_topic_score_gemma":0.0003629478,"domain_scores_codex":[0.9998842,0.00001615779,0.000007234796,0.00003452618,0.00003165639,0.00002606762],"domain_scores_gemma":[0.9998432,0.00002284353,0.00006350148,0.00002530609,0.000012951,0.00003211945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004739792,0.000008978643,0.0003340052,0.00002456665,0.000003875202,0.00005010192,0.00001961203,0.00009815094,0.9963863,0.0002292939,0.00004185238,0.002755867],"study_design_scores_gemma":[0.000005229651,0.0001012562,0.002007033,0.000003485493,0.000003690456,0.0003171717,0.000007403008,0.0004563883,0.9959449,0.00006740267,0.001082292,0.000003783922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883095,0.001619457,0.008372827,0.0001198347,0.00002299524,0.00001797231,0.00008166318,0.0002354302,0.001220307],"genre_scores_gemma":[0.9949897,0.0002764271,0.002410806,0.00003968014,0.000007361694,0.00001246426,0.0001117078,0.0000252078,0.002126597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285958,"threshold_uncertainty_score":0.004302025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141465288060936,"score_gpt":0.2162961832553772,"score_spread":0.2048815303747679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}