{"id":"W4200614063","doi":"10.1021/acs.joc.1c02518","title":"Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles","year":2021,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Cyclization and Aryne Chemistry","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Regioselectivity; Chemistry; Pyrazole; Combinatorial chemistry; Chemical synthesis; Stereochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002248785,0.0001807302,0.0003800034,0.00001436549,0.0000779941,0.00001795981,0.0004692521,0.0001585279,0.009745345],"category_scores_gemma":[0.0009182515,0.0001406995,0.0001888846,0.0003123185,0.0001371253,0.00007076238,0.000103893,0.000443589,0.000005718702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009655132,"about_ca_system_score_gemma":0.0003847285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001652142,"about_ca_topic_score_gemma":0.000001048431,"domain_scores_codex":[0.9986675,0.00002256364,0.0006234924,0.0001338153,0.0003635916,0.0001890824],"domain_scores_gemma":[0.9978901,0.0003584058,0.000738161,0.0004293821,0.0004738999,0.0001100532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006924971,0.0001245698,0.0003863945,0.0002115085,0.0001964184,0.00004598024,0.0002281586,0.00001478249,0.9969476,0.000002740486,0.001022139,0.0007504318],"study_design_scores_gemma":[0.000453706,0.000004018988,0.00007582711,0.000235986,0.0001854475,0.001253194,0.001317694,0.00002815758,0.9950353,0.0001431147,0.001125184,0.0001423885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746261,0.00139665,0.00007696647,0.0006367445,0.0000449224,0.0000125277,0.00001527807,0.00002390522,0.02316695],"genre_scores_gemma":[0.9960745,0.0008214086,0.00007252387,0.00004942498,0.0002455141,5.358877e-7,0.000005262121,0.00003281895,0.002698041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02144842,"threshold_uncertainty_score":0.9911599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006289275912528501,"score_gpt":0.2054572158760531,"score_spread":0.1991679399635246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}