{"id":"W4200616087","doi":"10.3389/fonc.2021.772920","title":"Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; University of Alberta; Alberta Cancer Foundation","keywords":"Cancer research; Sensitization; DNA damage; Chemistry; Kinase; DNA; Pharmacology; Molecular biology; Medicine; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351948,0.0001069275,0.0003345607,0.0000971363,0.00001958176,0.000002237637,0.00009115965,0.0001892685,0.00001184435],"category_scores_gemma":[0.00008754338,0.0001243385,0.00008699927,0.0002022532,0.00004636761,0.000004165198,0.00005988114,0.00004220236,1.019387e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009048789,"about_ca_system_score_gemma":0.0005595866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001769841,"about_ca_topic_score_gemma":0.0004392172,"domain_scores_codex":[0.9991032,0.00004598029,0.0003512532,0.0002462408,0.00008167125,0.0001716785],"domain_scores_gemma":[0.9992774,0.0000263111,0.0002220933,0.000161484,0.000261012,0.00005170262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000803534,0.0002352819,0.000664224,0.00005386974,0.0001038055,0.000002041964,0.0001881574,0.0003872787,0.9882106,0.0001848825,0.001890067,0.007276271],"study_design_scores_gemma":[0.002199606,0.0008697996,0.0007547439,0.00002747531,0.00004474892,0.000001518195,0.0002354663,0.0006487609,0.9891543,0.00005102065,0.005897302,0.0001153049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875627,0.001412605,0.00855721,0.0002513375,0.00109473,0.000378492,0.0007019364,0.000002427982,0.00003858322],"genre_scores_gemma":[0.9834124,0.0002424898,0.01552867,0.0002672212,0.00008997476,0.00005243211,0.0003363145,0.00002021461,0.0000503192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007160966,"threshold_uncertainty_score":0.5070378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128957820412795,"score_gpt":0.2746680501000927,"score_spread":0.2633784718959647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}