{"id":"W4200616087","doi":"10.3389/fonc.2021.772920","title":"Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; University of Alberta; Alberta Cancer Foundation","keywords":"Cancer research; Sensitization; DNA damage; Chemistry; Kinase; DNA; Pharmacology; Molecular biology; Medicine; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000727883,0.0001993579,0.0001847476,0.00009934788,0.0000762519,0.0001379064,0.0001215501,0.000252204,0.0003867696],"category_scores_gemma":[0.00006932138,0.00009247632,0.0001461614,0.00006758181,0.0001170541,0.0001371191,0.00009884771,0.0003099904,0.0001264254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434163,"about_ca_system_score_gemma":0.0001333241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007399194,"about_ca_topic_score_gemma":0.0008537653,"domain_scores_codex":[0.9999491,0.000005389843,0.000003508396,0.00001606926,0.0000168164,0.000009198366],"domain_scores_gemma":[0.9999706,0.000005812416,0.0000102839,0.000002486818,0.000004881399,0.000005994057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002419384,0.00001302662,0.0000248608,0.00002897784,0.000001957138,0.00001236732,0.000003554154,0.0001018567,0.998727,0.00002454821,0.00001300973,0.001024695],"study_design_scores_gemma":[0.000007336892,0.0001620218,0.0003818259,0.000001518556,0.000006644951,0.00006023,0.000002856483,0.0008193424,0.9977885,0.000007243045,0.0007602564,0.000002113551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844524,0.002677789,0.01111794,0.0001066588,0.00003720643,0.00005619305,0.0001056737,0.0001089272,0.001337255],"genre_scores_gemma":[0.9907619,0.001211326,0.006246312,0.00003957776,0.000006813579,0.00004469769,0.00008240631,0.00001331248,0.001593647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007399194,"threshold_uncertainty_score":0.001766086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128957820412795,"score_gpt":0.2746680501000927,"score_spread":0.2633784718959647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}