{"id":"W4205104224","doi":"10.3389/fimmu.2021.721917","title":"Case Report: Unmanipulated Matched Sibling Donor Hematopoietic Cell Transplantation In TBX1 Congenital Athymia: A Lifesaving Therapeutic Approach When Facing a Systemic Viral Infection","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Haploinsufficiency; Immunology; Transplantation; DiGeorge syndrome; Hematopoietic stem cell transplantation; Medicine; T cell; Immune system; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002591896,0.00149222,0.001431881,0.001686183,0.002276842,0.001623329,0.001132036,0.005240154,0.002386988],"category_scores_gemma":[0.001518025,0.000703563,0.001101333,0.001012675,0.00144537,0.001795752,0.001586784,0.003882422,0.0007207494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001301089,"about_ca_system_score_gemma":0.0007442225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001581443,"about_ca_topic_score_gemma":0.001730979,"domain_scores_codex":[0.9994518,0.00005070851,0.00005961718,0.0001665755,0.00007857087,0.0001928435],"domain_scores_gemma":[0.9992257,0.0001686667,0.0001582666,0.00007358536,0.00003250827,0.0003411244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00001855278,0.00002851614,0.001821781,0.00001645412,0.000004753061,0.9962533,0.00007672582,0.00004307521,0.0004618877,0.0001759824,0.0001480676,0.0009508544],"study_design_scores_gemma":[0.000004132823,0.00002387431,0.0006855805,0.000006438682,0.000003800783,0.9986346,0.00003574916,0.00008314085,0.0002249516,0.00006843677,0.0002256436,0.000003664444],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579545,0.01087384,0.008604454,0.006133241,0.0008907895,0.0002831282,0.000435769,0.0003785321,0.01444585],"genre_scores_gemma":[0.991552,0.002007515,0.002294302,0.0009661226,0.001056805,0.00003748405,0.0001188411,0.00003253479,0.001934422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005240154,"threshold_uncertainty_score":0.009440124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440727019716959,"score_gpt":0.245807031403863,"score_spread":0.2313997612066934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}