{"id":"W4205118511","doi":"10.1101/2022.01.20.477143","title":"<i>Caulobacter</i> requires anionic sphingolipids and deactivation of <i>fur</i> to lose lipid A","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Lawrence Berkeley National Laboratory; European Regional Development Fund; Fundacja na rzecz Nauki Polskiej; European Commission; Laboratory Directed Research and Development; U.S. Department of Energy; Consortium canadien en neurodégénérescence associée au vieillissement; National Institutes of Health; National Science Foundation","keywords":"Caulobacter crescentus; Lipid A; Sphingolipid; Ceramide; Lipid II; Biochemistry; Bacterial outer membrane; Cell biology; Response regulator; Biology; Lipidome; Chemistry; Lipopolysaccharide; Lipid metabolism; Enzyme; Escherichia coli; Gene; Biosynthesis; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492334,0.0003324578,0.0001790165,0.0001199353,0.0002001121,0.0004568739,0.0002839169,0.0002782842,0.0007173513],"category_scores_gemma":[0.0001634148,0.0001349341,0.0001876025,0.0001275173,0.0002857134,0.0001616216,0.0003194681,0.000575878,0.0004726273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000486836,"about_ca_system_score_gemma":0.00035465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003058952,"about_ca_topic_score_gemma":0.002002927,"domain_scores_codex":[0.9998257,0.00001493177,0.00001308607,0.00003253892,0.00006033915,0.00005345569],"domain_scores_gemma":[0.9998692,0.00001682722,0.00003415419,0.00003222872,0.0000167627,0.00003069566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002810576,0.00001179319,0.0002757013,0.000007863156,0.000001674341,0.00003837428,0.000007010229,0.00004300811,0.9990326,0.00009724255,0.00005890555,0.0003977789],"study_design_scores_gemma":[0.000009113826,0.00003045374,0.005186505,0.000003704856,0.000003505199,0.0002156192,0.00003152222,0.0009332683,0.9915679,0.00009219609,0.001921424,0.000004843881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945434,0.0002821256,0.002121301,0.0002253981,0.00003077146,0.00001283357,0.0003545429,0.0001915596,0.002237875],"genre_scores_gemma":[0.9959515,0.00009241312,0.001438634,0.00008949558,0.00000585854,0.0000101283,0.0005347435,0.00006048746,0.00181675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003058952,"threshold_uncertainty_score":0.006082296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008332572083387904,"score_gpt":0.2155205348978814,"score_spread":0.2071879628144935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}