{"id":"W4205121832","doi":"10.1093/stcltm/szab007","title":"Robust In Vitro and In Vivo Immunosuppressive and Anti-inflammatory Properties of Inducible Caspase-9-mediated Apoptotic Mesenchymal Stromal/Stem Cell","year":2022,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; Ministerio de Ciencia e Innovación","keywords":"Mesenchymal stem cell; In vivo; Apoptosis; Cytotoxic T cell; Suicide gene; Cancer research; Immunology; Stromal cell; Stem cell; Biology; In vitro; Medicine; Cell biology; Genetic enhancement","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003753572,0.0005480251,0.0004002582,0.0002961626,0.0001011528,0.000398958,0.0001677346,0.0002851695,0.001224935],"category_scores_gemma":[0.0002176577,0.000101043,0.0003829479,0.0001790732,0.0002626507,0.0002378252,0.0001574583,0.001090421,0.0003710371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315002,"about_ca_system_score_gemma":0.000225409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001422069,"about_ca_topic_score_gemma":0.0002212898,"domain_scores_codex":[0.9995754,0.00008797914,0.00005313835,0.00007605702,0.0001393198,0.00006811104],"domain_scores_gemma":[0.999731,0.00006035197,0.00007844336,0.00005219473,0.00003719865,0.00004084538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000146022,0.0000966424,0.0001766674,0.00005793478,0.000009159159,0.00003517845,0.00001552395,0.00006854757,0.9960288,0.00005610537,0.00002591517,0.003283527],"study_design_scores_gemma":[0.0000110769,0.0006565456,0.001003844,0.000002925612,0.00001872393,0.0001417532,0.00000960683,0.0002509327,0.9971958,0.00002141002,0.0006858091,0.000001367163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831054,0.002907753,0.01147818,0.00009528455,0.00007427621,0.0000842495,0.0005038538,0.0001515229,0.001599486],"genre_scores_gemma":[0.9926992,0.00100778,0.004403834,0.00004437237,0.00002082724,0.00005778976,0.0006690671,0.00002413379,0.001072957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224935,"threshold_uncertainty_score":0.004097819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429978564285998,"score_gpt":0.2028614578713848,"score_spread":0.1885616722285249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}