{"id":"W4205133460","doi":"10.1016/j.bbi.2022.01.007","title":"Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson’s disease mice","year":2022,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Deutsche Stiftung Neurologie; Julius-Maximilians-Universität Würzburg; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; Ministry of Education, India; European Commission; Stiftung VERUM; Alexander von Humboldt-Stiftung","keywords":"Neurodegeneration; Parkinson's disease; Alpha-synuclein; Disease; Synuclein; Medicine; Neuroscience; Virology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005482688,0.001021965,0.000628218,0.001446512,0.0004257046,0.0007177144,0.0004990908,0.001381145,0.001879785],"category_scores_gemma":[0.0002119777,0.0007178789,0.000847122,0.0003779655,0.0006616193,0.000498027,0.0003447263,0.002287521,0.001186695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005017093,"about_ca_system_score_gemma":0.0003168079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008470406,"about_ca_topic_score_gemma":0.001200298,"domain_scores_codex":[0.9992614,0.00009634045,0.0001339357,0.0002436731,0.0001319133,0.0001328168],"domain_scores_gemma":[0.9995375,0.00006166415,0.0001438893,0.00005853928,0.00003997,0.0001584763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001705841,0.0001462204,0.0001210569,0.00003289969,0.0000106485,0.00009558205,0.00005469153,0.0001012219,0.9985697,0.0001115564,0.00005837439,0.0005274545],"study_design_scores_gemma":[0.0003312808,0.002124949,0.004224795,0.00004740791,0.00009938467,0.00110871,0.0001057192,0.003543566,0.9840356,0.0002566901,0.004100231,0.00002171383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98579,0.001660336,0.006444857,0.0003309484,0.0001824969,0.0003826144,0.002132347,0.0004289796,0.002647485],"genre_scores_gemma":[0.9751037,0.001587875,0.01060774,0.0003047909,0.00008205973,0.000521727,0.002424467,0.0001610932,0.009206572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879785,"threshold_uncertainty_score":0.006288469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01926250790770247,"score_gpt":0.2469449662769684,"score_spread":0.2276824583692659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}