{"id":"W4205138908","doi":"10.1007/s00018-021-04042-y","title":"eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Enos; Neovascularization; Retinal; Endothelial stem cell; Sprouting angiogenesis; Sprouting; Ophthalmology; Medicine; Angiogenesis; Cell biology; Biology; Internal medicine; Nitric oxide; Biochemistry; Botany; Nitric oxide synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175363,0.000215216,0.0002083713,0.0002047408,0.0001566479,0.0003528969,0.0001500447,0.00018333,0.0005243639],"category_scores_gemma":[0.0001131615,0.0001432503,0.0001806758,0.0000930151,0.0002158665,0.0002127502,0.0002262492,0.0003814693,0.0001879577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196763,"about_ca_system_score_gemma":0.0001503671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006263467,"about_ca_topic_score_gemma":0.0006692159,"domain_scores_codex":[0.9998416,0.00002510418,0.00001345356,0.00003945121,0.00003850628,0.00004189023],"domain_scores_gemma":[0.9998649,0.00000777292,0.00004662005,0.0000103674,0.00001682084,0.00005352227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000970545,0.00001316785,0.0003483915,0.00001595664,0.000002428234,0.00005626498,0.000011935,0.00003092192,0.9980844,0.000157725,0.00002318687,0.001158565],"study_design_scores_gemma":[0.00003771115,0.0002294978,0.05937378,0.000008708517,0.00003486368,0.0004041646,0.0000643751,0.002745994,0.9322038,0.0003699521,0.00451481,0.00001232225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909639,0.002227993,0.004284239,0.00009101368,0.00003152556,0.00001632153,0.0001970252,0.00009932089,0.002088603],"genre_scores_gemma":[0.9958473,0.0008590808,0.001080646,0.00002843626,0.000009084632,0.00001408997,0.0001203787,0.0000177243,0.002023192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006263467,"threshold_uncertainty_score":0.001754224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124184981748741,"score_gpt":0.2366637646641927,"score_spread":0.2254219148467053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}