{"id":"W4205138908","doi":"10.1007/s00018-021-04042-y","title":"eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Enos; Neovascularization; Retinal; Endothelial stem cell; Sprouting angiogenesis; Sprouting; Ophthalmology; Medicine; Angiogenesis; Cell biology; Biology; Internal medicine; Nitric oxide; Biochemistry; Botany; Nitric oxide synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004045897,0.0001185411,0.0001407497,0.00001916168,0.000253882,0.00004558014,0.0001202962,0.00009391107,0.00001166474],"category_scores_gemma":[0.0001131448,0.00009133217,0.0001186263,0.0001558266,0.0003865462,0.00001092857,0.0001187152,0.00004583841,4.83175e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003548861,"about_ca_system_score_gemma":0.0001426787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004807064,"about_ca_topic_score_gemma":0.000006771451,"domain_scores_codex":[0.9988929,0.000144275,0.0002021898,0.0003710662,0.0002089953,0.0001805457],"domain_scores_gemma":[0.9994969,0.00001935741,0.0001168293,0.0002103063,0.0001043324,0.0000522335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000142862,0.00001781543,0.003040183,0.00001821844,0.00002925064,0.000001861264,0.0001025051,0.00007222673,0.9946555,0.001560197,0.0000297698,0.0004581233],"study_design_scores_gemma":[0.0003959691,0.0001040688,0.002055452,0.00001352918,0.00004789669,0.00001543325,0.0002793721,0.0003122281,0.9894088,0.000429199,0.006806573,0.0001315012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9358724,0.03232303,0.03017617,0.0003625231,0.00008903528,0.0001600826,0.00001322124,0.000004971314,0.0009985707],"genre_scores_gemma":[0.9969438,0.0008459508,0.001487129,0.0004756729,0.0001157677,0.000005784577,0.00003004182,0.000009319427,0.00008652609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06107142,"threshold_uncertainty_score":0.3724418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124184981748741,"score_gpt":0.2366637646641927,"score_spread":0.2254219148467053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}