{"id":"W4205166811","doi":"10.3389/fcvm.2021.788270","title":"Cardioprotective Effects of n-3 Polyunsaturated Fatty Acids: Orchestration of mRNA Expression, Protein Phosphorylation, and Lipid Metabolism in Pressure Overload Hearts","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; York University; University of Toronto","funders":"Science and Technology Planning Project of Guangdong Province; Guangzhou Municipal Science and Technology Project; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Pressure overload; Internal medicine; Endocrinology; Biology; Phospholamban; Mitochondrion; Polyunsaturated fatty acid; Phosphorylation; Cell biology; Muscle hypertrophy; Biochemistry; Medicine; Fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399652,0.0004546426,0.0002689866,0.00026042,0.0002643518,0.0002420551,0.0001713662,0.0003150078,0.0008152716],"category_scores_gemma":[0.00007753958,0.0001701686,0.0003592697,0.0001652607,0.000322514,0.0003013019,0.0002691197,0.0004908354,0.0002018142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762061,"about_ca_system_score_gemma":0.0002113305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000497299,"about_ca_topic_score_gemma":0.0009746412,"domain_scores_codex":[0.9998958,0.000007338965,0.000008158711,0.0000419244,0.00002067652,0.00002621486],"domain_scores_gemma":[0.9998916,0.000007470961,0.00003982247,0.000008811746,0.0000185495,0.00003364494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403765,0.00001557776,0.0003603842,0.00005106309,0.000005603647,0.0000342234,0.00001213303,0.00001439818,0.9985549,0.00002472629,0.00002427133,0.0006624027],"study_design_scores_gemma":[0.00009027425,0.0007365901,0.1105735,0.00005734717,0.0001506777,0.0003785361,0.0001531357,0.0009498711,0.8834106,0.0003013797,0.003165566,0.00003239846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899526,0.004755902,0.003041659,0.0001790457,0.0000682747,0.00003697828,0.0008264664,0.00007986949,0.001059051],"genre_scores_gemma":[0.9901977,0.002968419,0.003508344,0.0001667758,0.0000410491,0.0001133973,0.0008237351,0.00004103739,0.002139537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008152716,"threshold_uncertainty_score":0.00272733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003816441031893809,"score_gpt":0.1917656697177633,"score_spread":0.1879492286858695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}