{"id":"W4205166811","doi":"10.3389/fcvm.2021.788270","title":"Cardioprotective Effects of n-3 Polyunsaturated Fatty Acids: Orchestration of mRNA Expression, Protein Phosphorylation, and Lipid Metabolism in Pressure Overload Hearts","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; York University; University of Toronto","funders":"Science and Technology Planning Project of Guangdong Province; Guangzhou Municipal Science and Technology Project; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Pressure overload; Internal medicine; Endocrinology; Biology; Phospholamban; Mitochondrion; Polyunsaturated fatty acid; Phosphorylation; Cell biology; Muscle hypertrophy; Biochemistry; Medicine; Fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001045883,0.000205787,0.0007981232,0.0002148305,0.0000643022,0.000003517256,0.0001573557,0.0001537338,0.000005926615],"category_scores_gemma":[0.0003246145,0.0001798749,0.0001928348,0.0003883006,0.0001775939,0.00001417492,0.0001233636,0.0002147915,5.818744e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002132603,"about_ca_system_score_gemma":0.00009404923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002171803,"about_ca_topic_score_gemma":0.000005407032,"domain_scores_codex":[0.9978901,0.0005104207,0.0004358381,0.0004489865,0.0005043908,0.0002102434],"domain_scores_gemma":[0.9991523,0.0000155634,0.000166346,0.0005037446,0.0001018882,0.00006017464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004926832,0.0000907962,0.01262194,0.0003624775,0.0007036948,0.000008973419,0.0009658374,0.0007186512,0.9733773,0.000008396194,0.000302402,0.01034683],"study_design_scores_gemma":[0.002366807,0.0001642513,0.1129986,0.0001500109,0.0002134574,0.000007851272,0.0005211908,0.00004755272,0.8608963,0.00003561115,0.02242035,0.0001779484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8179362,0.1762157,0.003809688,0.00004140698,0.0006170109,0.00128325,0.00002150927,0.000008350697,0.00006691884],"genre_scores_gemma":[0.9973267,0.0003518823,0.001740761,0.00001999043,0.000231722,0.0002016787,0.00006712029,0.00002143286,0.00003874715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1793905,"threshold_uncertainty_score":0.7335085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003816441031893809,"score_gpt":0.1917656697177633,"score_spread":0.1879492286858695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}