{"id":"W4205194661","doi":"10.1200/jco.21.01918","title":"Treatment Exposure and Discontinuation in the PALbociclib CoLlaborative Adjuvant Study of Palbociclib With Adjuvant Endocrine Therapy for Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Early Breast Cancer (PALLAS/AFT-05/ABCSG-42/BIG-14-03)","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Palbociclib; Discontinuation; Adjuvant; Breast cancer; Cancer; Endocrine system; Adjuvant therapy; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009661064,0.0006417597,0.001228899,0.0003341852,0.0004055667,0.001049962,0.001018758,0.00101913,0.001965401],"category_scores_gemma":[0.006583969,0.000499121,0.0022885,0.00066895,0.0004073816,0.0007102692,0.0007013428,0.00182457,0.0002029616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009383055,"about_ca_system_score_gemma":0.001434794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00172662,"about_ca_topic_score_gemma":0.002716363,"domain_scores_codex":[0.9951538,0.00322298,0.0002265803,0.0005838771,0.0004842146,0.0003285612],"domain_scores_gemma":[0.9950678,0.001515751,0.002014048,0.0005177654,0.0002067647,0.000677782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6631676,0.004431057,0.2770185,0.0004749999,0.009594813,0.0001881861,0.0001856359,0.001292095,0.002063237,0.000200996,0.001827869,0.03955491],"study_design_scores_gemma":[0.1235909,0.08608612,0.771816,0.0001452558,0.008210662,0.0003485045,0.0001481491,0.003814971,0.0008794464,0.0005098351,0.004371409,0.0000788496],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959385,0.00172235,0.0003187422,0.0001779359,0.00005220342,0.0003073563,0.0008297049,0.00001336662,0.0006397621],"genre_scores_gemma":[0.9967731,0.0003780966,0.0002857678,0.0002772288,0.00009276018,0.0003840625,0.001132862,0.0000070044,0.0006691535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009661064,"threshold_uncertainty_score":0.05109322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0664875891783569,"score_gpt":0.410618722763568,"score_spread":0.3441311335852111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}