{"id":"W4205194661","doi":"10.1200/jco.21.01918","title":"Treatment Exposure and Discontinuation in the PALbociclib CoLlaborative Adjuvant Study of Palbociclib With Adjuvant Endocrine Therapy for Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Early Breast Cancer (PALLAS/AFT-05/ABCSG-42/BIG-14-03)","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Palbociclib; Discontinuation; Adjuvant; Breast cancer; Cancer; Endocrine system; Adjuvant therapy; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001355672,0.0004376865,0.002463436,0.0002168528,0.0002551405,0.00002228934,0.0002895877,0.0001482175,0.0001684278],"category_scores_gemma":[0.0004014097,0.0002521602,0.0003064464,0.00050764,0.0004700444,0.0002862653,0.00007595088,0.001006336,6.719639e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007061326,"about_ca_system_score_gemma":0.001262294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004692033,"about_ca_topic_score_gemma":0.001110109,"domain_scores_codex":[0.9936079,0.002184022,0.002439102,0.0005190182,0.0007983013,0.0004516561],"domain_scores_gemma":[0.9917752,0.003392061,0.003078058,0.0002864143,0.001220575,0.0002477573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1273089,0.0154756,0.4533872,0.00003024042,0.002993738,0.0003273558,0.03377511,0.00006814067,0.004564296,0.00008756015,0.0003747579,0.3616071],"study_design_scores_gemma":[0.07418206,0.1353012,0.7673463,0.00008227037,0.0003730261,0.0002055538,0.01933425,0.00001001375,0.0004428276,0.0001205115,0.002367406,0.000234613],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825742,0.002168362,0.00005098151,0.01108166,0.0004784928,0.003032062,0.0005532372,0.00001309162,0.00004797255],"genre_scores_gemma":[0.994612,0.001980382,0.0009670894,0.0007100919,0.000853266,0.0006542515,0.00002746208,0.00006026628,0.0001351837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3613725,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0664875891783569,"score_gpt":0.410618722763568,"score_spread":0.3441311335852111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}