{"id":"W4205199571","doi":"10.3389/fphar.2021.810704","title":"Acute Oral, Subacute, and Developmental Toxicity Profiling of Naphthalene 2-Yl, 2-Chloro, 5-Nitrobenzoate: Assessment Based on Stress Response, Toxicity, and Adverse Outcome Pathways","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"","keywords":"Toxicity; Adverse Outcome Pathway; Developmental toxicity; Alkaline phosphatase; Adverse effect; Pharmacology; Reproductive toxicity; Acute toxicity; Kidney; Glutathione; Medicine; Physiology; Biology; Internal medicine; Fetus; Enzyme; Biochemistry; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007514497,0.0002861565,0.0004351175,0.0002688781,0.0002140511,0.00001175271,0.0002396683,0.0001373308,0.00008087467],"category_scores_gemma":[0.0000222476,0.0003125807,0.00008390815,0.0001984552,0.000177549,0.00001063452,0.0005474935,0.0003244565,2.719667e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221006,"about_ca_system_score_gemma":0.0002907068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001684982,"about_ca_topic_score_gemma":0.00001953817,"domain_scores_codex":[0.9977321,0.0004886126,0.0004681061,0.0006194618,0.0002761947,0.0004155265],"domain_scores_gemma":[0.9993888,0.00005583222,0.0001832215,0.0001895047,0.00005030963,0.0001323974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002967214,0.000570946,0.1837208,0.00005252911,0.0001794431,0.000104523,0.00007345133,0.0009594742,0.8087085,0.00001476896,0.002075045,0.0005732712],"study_design_scores_gemma":[0.006128608,0.00217047,0.04936447,0.00001204268,0.0001289989,0.00006513159,0.001284798,0.004477773,0.933057,0.00003898082,0.002750911,0.000520877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960326,0.000254597,0.00131498,0.0002278432,0.0006189456,0.0006593306,0.0006978328,0.00001345106,0.0001804451],"genre_scores_gemma":[0.9844654,0.0001385329,0.01388795,0.0009778942,0.00003672684,0.000187902,0.0001814453,0.00003031675,0.00009387164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1343563,"threshold_uncertainty_score":0.9999326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619691269793988,"score_gpt":0.2963113679630305,"score_spread":0.2801144552650907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}