{"id":"W4205199571","doi":"10.3389/fphar.2021.810704","title":"Acute Oral, Subacute, and Developmental Toxicity Profiling of Naphthalene 2-Yl, 2-Chloro, 5-Nitrobenzoate: Assessment Based on Stress Response, Toxicity, and Adverse Outcome Pathways","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"","keywords":"Toxicity; Adverse Outcome Pathway; Developmental toxicity; Alkaline phosphatase; Adverse effect; Pharmacology; Reproductive toxicity; Acute toxicity; Kidney; Glutathione; Medicine; Physiology; Biology; Internal medicine; Fetus; Enzyme; Biochemistry; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003275134,0.0005390607,0.0003046049,0.0006296998,0.0002754445,0.0002333524,0.0002049258,0.0003178062,0.001020015],"category_scores_gemma":[0.0001835937,0.0001327885,0.0004434932,0.0003770733,0.0002058274,0.000218529,0.0002462791,0.0004138957,0.0001694549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307204,"about_ca_system_score_gemma":0.0005331333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890603,"about_ca_topic_score_gemma":0.005253252,"domain_scores_codex":[0.9997073,0.00004235348,0.0000255548,0.00004663066,0.0001432347,0.00003494434],"domain_scores_gemma":[0.999756,0.0000177924,0.00006428167,0.00001725858,0.0001098095,0.00003495168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001198554,0.00007018292,0.00160574,0.0001201405,0.00001956627,0.00004416961,0.00003237347,0.0001467218,0.9938847,0.00004534476,0.00006179172,0.003849274],"study_design_scores_gemma":[0.000009029549,0.003388316,0.02805309,0.00002804667,0.0001006901,0.0001911307,0.00009451598,0.000490527,0.9643551,0.00008106692,0.003193694,0.000014674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816005,0.005214531,0.008440803,0.0001136378,0.00004596642,0.0002047453,0.001499225,0.00005933766,0.002821155],"genre_scores_gemma":[0.9712685,0.007392019,0.009468459,0.0001538087,0.00001956762,0.0002708638,0.00312316,0.00002305174,0.008280488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001890603,"threshold_uncertainty_score":0.003759205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619691269793988,"score_gpt":0.2963113679630305,"score_spread":0.2801144552650907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}