{"id":"W4205202542","doi":"10.1038/s41467-021-27881-6","title":"Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Hamilton Health Sciences Foundation; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; University of Bristol; Elizabeth Blackwell Institute for Health Research, University of Bristol; Weizmann Institute of Science; Wellcome; Imperial College London; Research Councils UK; British Society for Antimicrobial Chemotherapy; U.S. Food and Drug Administration; Max-Planck-Gesellschaft; Engineering and Physical Sciences Research Council; Heidelberg Biosciences International Graduate School; UK Research and Innovation; Wellcome Trust","keywords":"Viral quasispecies; Biology; Tropism; Furin; Infectivity; Genetics; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Tissue tropism; Cell type; Viral entry; Coronavirus; Virology; Evolutionary biology; Computational biology; Coronavirus disease 2019 (COVID-19); Cell; Gene; Virus; Viral replication; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009593668,0.0001888988,0.0001635539,0.00009818822,0.0002074961,0.0002970973,0.0002604947,0.0002972035,0.00149564],"category_scores_gemma":[0.0001350535,0.0001469274,0.000166775,0.00008590058,0.0002538583,0.0003895675,0.0001937565,0.0005716948,0.0002832375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003294723,"about_ca_system_score_gemma":0.0002117654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009832662,"about_ca_topic_score_gemma":0.001815684,"domain_scores_codex":[0.9999616,0.000005010064,0.000001502546,0.000007943529,0.0000120067,0.00001181432],"domain_scores_gemma":[0.9999529,0.0000106972,0.00001201463,0.000005565078,0.000004964026,0.00001381724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002236013,0.00007391557,0.002642071,0.00004716505,0.00001201566,0.000503288,0.0001661578,0.008887892,0.9815186,0.003368239,0.0002547356,0.002302182],"study_design_scores_gemma":[0.0002101246,0.0009961448,0.0747228,0.00004962652,0.00007558104,0.002197258,0.001478598,0.3221395,0.5733017,0.008140965,0.01657864,0.0001090068],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965066,0.000228694,0.001597307,0.0001453452,0.00001085951,0.000005877317,0.00007360655,0.00003597842,0.001395695],"genre_scores_gemma":[0.9983094,0.0001907724,0.0008825828,0.00004827461,0.000003955935,0.000003343743,0.0001254096,0.000007288127,0.0004290027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149564,"threshold_uncertainty_score":0.005003393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04726163368995798,"score_gpt":0.3383002182636451,"score_spread":0.2910385845736871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}