{"id":"W4205210641","doi":"10.1098/rsob.210255","title":"Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria","year":2022,"lang":"en","type":"article","venue":"Open Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Parkin; Mitophagy; PINK1; Ubiquitin; Ubiquitin ligase; MFN2; Biology; Mitochondrion; Cell biology; Biochemistry; Autophagy; mitochondrial fusion; Mitochondrial DNA; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892506,0.0001702481,0.0001981564,0.000108273,0.0001800066,0.0003100537,0.0001286047,0.0002323047,0.0007300959],"category_scores_gemma":[0.0001762361,0.0001375318,0.0001428475,0.00009563344,0.0001906417,0.0002909037,0.0003196744,0.0002138468,0.0002807094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003511449,"about_ca_system_score_gemma":0.0001233885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003616914,"about_ca_topic_score_gemma":0.0005730133,"domain_scores_codex":[0.9998649,0.00002554007,0.000009528405,0.00003793332,0.00002784407,0.00003412402],"domain_scores_gemma":[0.9999102,0.00001416487,0.00002805519,0.00001195674,0.000007287196,0.00002830664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006502863,0.000006306648,0.0002146439,0.00001009512,0.000001539814,0.00005687091,0.00001253875,0.00004061254,0.9990633,0.0001016293,0.00001567194,0.0004117327],"study_design_scores_gemma":[0.000006681752,0.00006216906,0.003720277,0.000003283197,0.000003995625,0.0005267884,0.00001799254,0.0007916943,0.9932857,0.00004664902,0.001531297,0.000003489726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966858,0.0005514098,0.001910035,0.00004445045,0.000005399852,0.000005632684,0.00003700472,0.00002929493,0.000731091],"genre_scores_gemma":[0.9986532,0.0001027799,0.0007493298,0.00001606543,0.000001972239,0.000003760651,0.00004269201,0.000006792186,0.0004233748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007300959,"threshold_uncertainty_score":0.002547741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0212622655030176,"score_gpt":0.3203782330783434,"score_spread":0.2991159675753258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}