{"id":"W4205218195","doi":"10.51731/cjht.2021.189","title":"Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta)","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ivacaftor; Reimbursement; Cystic fibrosis; Medicine; Cystic fibrosis transmembrane conductance regulator; Drug; Regulator; Internal medicine; Pharmacology; Gene; Political science; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007157243,0.0002183943,0.0007548436,0.0007650146,0.0002857006,0.00007821341,0.0002903199,0.0002250107,0.0001250712],"category_scores_gemma":[0.004222911,0.0001898428,0.0001209132,0.000615585,0.000502289,0.00021415,0.00007351978,0.0009147535,0.00001579485],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006743928,"about_ca_system_score_gemma":0.007607045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007462091,"about_ca_topic_score_gemma":0.0000908304,"domain_scores_codex":[0.9975058,0.00009842088,0.0007861942,0.000296431,0.0004363183,0.0008768064],"domain_scores_gemma":[0.997905,0.0001905286,0.0003528101,0.0004436254,0.000605795,0.0005022485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001783009,0.00009480164,0.07017008,0.001098161,0.0002360772,0.004478286,0.00003588198,0.000003635588,0.007288065,0.002992114,0.02672381,0.8867008],"study_design_scores_gemma":[0.001581283,0.00126297,0.09613866,0.0009432632,0.00004058993,0.005097952,0.003541654,0.00001233707,0.009017619,0.002383149,0.8797184,0.0002621024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7842721,0.2023766,0.0001838213,0.01240369,0.00004584693,0.0002565567,0.00003529043,0.00009854614,0.0003275123],"genre_scores_gemma":[0.9872466,0.003466666,0.008109739,0.000688027,0.00005961508,0.000008061042,0.000006371481,0.00003226626,0.0003826792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8864387,"threshold_uncertainty_score":0.9980189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552972659179446,"score_gpt":0.3199476655061916,"score_spread":0.2944179389143971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}