{"id":"W4205220350","doi":"10.1016/j.jaci.2021.10.040","title":"Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Sanofi; Mylan; GlaxoSmithKline; Johns Hopkins University; Teva Pharmaceutical Industries; AstraZeneca","keywords":"Nasal polyps; Mepolizumab; Eosinophil; Medicine; Chronic rhinosinusitis; Comorbidity; Internal medicine; Complete blood count; Gastroenterology; Dermatology; Immunology; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002575983,0.0001560037,0.0005976042,0.00008212937,0.0003223984,0.00001662036,0.0000800548,0.0001162719,0.0002117616],"category_scores_gemma":[0.00006486267,0.0001146683,0.00016772,0.00007378077,0.0003410367,0.00006045515,0.00005820314,0.0004322469,7.716498e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001283774,"about_ca_system_score_gemma":0.0003519383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008566202,"about_ca_topic_score_gemma":0.00007156969,"domain_scores_codex":[0.9986585,0.0001481056,0.0006070567,0.0002045741,0.0001559091,0.000225857],"domain_scores_gemma":[0.9986773,0.0005391653,0.0003615548,0.000149002,0.0001259879,0.0001470065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.14581,0.0742543,0.1531172,0.000305179,0.1379987,0.01401466,0.00357169,0.0001062219,0.06495109,0.02041729,0.106543,0.2789107],"study_design_scores_gemma":[0.07522923,0.1559863,0.5795399,0.0001606654,0.002462414,0.02542568,0.0005402892,0.00008415384,0.0008838892,0.00023867,0.1589958,0.0004530395],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835072,0.01329651,0.00004851018,0.002419217,0.0003454948,0.0002167306,0.00008124534,0.00001099668,0.00007413569],"genre_scores_gemma":[0.9923859,0.006155207,0.0002077787,0.0005306892,0.0003327744,0.00001550417,0.00004441754,0.00001914342,0.0003086015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4264227,"threshold_uncertainty_score":0.4676039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02520667489770572,"score_gpt":0.3202008783199127,"score_spread":0.2949942034222069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}