{"id":"W4205229401","doi":"10.3390/biomedicines10010127","title":"Interplay of Oxidative Stress and Necrosis-like Cell Death in Cardiac Ischemia/Reperfusion Injury: A Focus on Necroptosis","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Magyar Tudományos Akadémia; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; European Commission; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Agentúra na Podporu Výskumu a Vývoja; Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky","keywords":"Necroptosis; Programmed cell death; Oxidative stress; Mitochondrial permeability transition pore; Kinase; Signal transduction; Mitochondrion; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602187,0.0001273119,0.0001880699,0.0001254596,0.00006551979,0.000005215164,0.00008930547,0.00007551074,0.00002814894],"category_scores_gemma":[0.00001198025,0.0001063322,0.0000520954,0.0001505887,0.00005598669,0.000002649927,0.0001975566,0.000075135,4.301003e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001942163,"about_ca_system_score_gemma":0.00002880302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000224061,"about_ca_topic_score_gemma":0.00001039373,"domain_scores_codex":[0.9991776,0.00006070158,0.000187152,0.0002861148,0.0001528989,0.0001354707],"domain_scores_gemma":[0.9996208,0.00001414511,0.00009343048,0.0001927114,0.00003181752,0.00004709564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001996958,0.0001030604,0.005884115,0.00003159818,0.0000151536,0.000001439662,0.0002229406,0.00001813309,0.9891133,0.00003991465,0.0004973513,0.003873287],"study_design_scores_gemma":[0.0005717177,0.001173098,0.001923331,0.00004347642,0.00002024369,0.000001493813,0.0004920826,0.00008895214,0.9914664,0.00006432852,0.004027939,0.0001269199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978943,0.001008198,0.00009831236,0.0001347575,0.0002464802,0.0001952545,0.00008584069,0.000005299089,0.0003315498],"genre_scores_gemma":[0.9985879,0.0004310454,0.0002251475,0.00006963366,0.00007548128,0.00003705192,0.0001604317,0.00001430396,0.0003989998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003960784,"threshold_uncertainty_score":0.43361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005768885523899167,"score_gpt":0.2427267472711191,"score_spread":0.2369578617472199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}