{"id":"W4205230462","doi":"10.1139/bcb-2021-0409","title":"Metformin exerts anti-tumor effects via Sonic hedgehog signaling pathway by targeting AMPK in HepG2 cells","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metformin; Sonic hedgehog; AMPK; Hedgehog signaling pathway; Cancer research; Signal transduction; Chemistry; Pharmacology; Cell biology; Endocrinology; Biology; Diabetes mellitus; Phosphorylation; Protein kinase A","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368402,0.0002704485,0.0003253862,0.0002658772,0.0002186822,0.0002094583,0.0001186048,0.0001857948,0.001165054],"category_scores_gemma":[0.00005810363,0.0001320366,0.0002852287,0.0002150117,0.0001498181,0.0001715161,0.0001132633,0.0004214754,0.0002863699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213098,"about_ca_system_score_gemma":0.0002744879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164893,"about_ca_topic_score_gemma":0.00253072,"domain_scores_codex":[0.9999145,0.00001780476,0.00001339715,0.00001275761,0.00001961281,0.00002182988],"domain_scores_gemma":[0.9999766,0.00000330039,0.000006392685,0.000003006248,0.000003524199,0.000007043187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007611118,0.0001633205,0.0004846961,0.0001578696,0.00001776373,0.0001273695,0.00002257967,0.0001448298,0.9945287,0.0001459267,0.0001870665,0.003258695],"study_design_scores_gemma":[0.0002134981,0.001184251,0.01248423,0.00001304708,0.00007069305,0.0002736027,0.00008398531,0.001884722,0.9785413,0.00009839424,0.005138859,0.00001348025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893674,0.004375529,0.001938566,0.0003172546,0.0001438002,0.00004928084,0.0005997082,0.00009712495,0.003111428],"genre_scores_gemma":[0.991441,0.002994889,0.001710318,0.0001247184,0.00003392302,0.00009507626,0.0007366986,0.00001495656,0.002848462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165054,"threshold_uncertainty_score":0.003897548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00460148406615937,"score_gpt":0.2034141185928871,"score_spread":0.1988126345267277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}