{"id":"W4205239057","doi":"10.1016/j.ymthe.2022.01.020","title":"Passive immunization against phosphorylated tau improves features of Huntington's disease pathology","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Huntingtin; Huntington's disease; Huntingtin Protein; Hyperphosphorylation; Gliosis; Neurodegeneration; Induced pluripotent stem cell; Biology; Tau protein; Pathology; Neuroscience; Neurite; Disease; Cell biology; Medicine; Alzheimer's disease; Phosphorylation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007089573,0.0001905393,0.0001793582,0.0001128561,0.0002740709,0.00002651145,0.0004177633,0.00002721865,0.0001021024],"category_scores_gemma":[0.0002408578,0.0001918567,0.0001305546,0.0004375204,0.0001454744,0.00004433077,0.0001797332,0.0001682281,0.000004468996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002764068,"about_ca_system_score_gemma":0.0001015019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006431854,"about_ca_topic_score_gemma":2.572118e-7,"domain_scores_codex":[0.9980143,0.0006667744,0.0002145124,0.0004773721,0.0003747615,0.0002522528],"domain_scores_gemma":[0.9990801,0.00005842774,0.0001994706,0.0004968434,0.00007394372,0.0000912379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872612,0.0002393281,0.0001815025,0.000005650125,0.00001039108,0.00007032435,0.0002242923,0.002648989,0.9856627,0.0007046323,0.000101428,0.009963522],"study_design_scores_gemma":[0.000676845,0.0001961925,0.01399235,0.000002935288,0.00001068863,0.000002011198,0.00005648165,0.0001139965,0.9835817,0.0005309785,0.0006563121,0.0001795162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974703,0.0008279431,0.000269493,0.0004249041,0.0002317605,0.0004557212,0.00008931122,0.00006532766,0.0001652307],"genre_scores_gemma":[0.9958049,0.0002196896,0.00006600753,0.003486692,0.00001378275,0.0001385677,0.00005381609,0.00004888803,0.0001676621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01381085,"threshold_uncertainty_score":0.782369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00903075629490662,"score_gpt":0.2351846730745192,"score_spread":0.2261539167796126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}