{"id":"W4205239057","doi":"10.1016/j.ymthe.2022.01.020","title":"Passive immunization against phosphorylated tau improves features of Huntington's disease pathology","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Huntingtin; Huntington's disease; Huntingtin Protein; Hyperphosphorylation; Gliosis; Neurodegeneration; Induced pluripotent stem cell; Biology; Tau protein; Pathology; Neuroscience; Neurite; Disease; Cell biology; Medicine; Alzheimer's disease; Phosphorylation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255296,0.0007889212,0.0006231908,0.0004474602,0.0002077707,0.0003342904,0.0004470056,0.0008425821,0.002009832],"category_scores_gemma":[0.000188112,0.0001638751,0.0002597069,0.000121097,0.0004341255,0.0004622895,0.0001709846,0.00169038,0.0004580085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002478009,"about_ca_system_score_gemma":0.0002921236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004525105,"about_ca_topic_score_gemma":0.0004570272,"domain_scores_codex":[0.9998636,0.00001779296,0.00001138129,0.00003980795,0.00002672513,0.00004071622],"domain_scores_gemma":[0.9998428,0.00002381339,0.00003154268,0.00002273295,0.00002319653,0.00005587227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001648829,0.00175879,0.0002623266,0.00007433728,0.00003498118,0.0001106805,0.00004240173,0.0001529424,0.9877428,0.0002466968,0.0003086662,0.007616642],"study_design_scores_gemma":[0.001042426,0.01482699,0.009668868,0.00005581784,0.0002241801,0.00107057,0.00008862034,0.002318848,0.9643964,0.000710736,0.005574199,0.00002235921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929292,0.0009917853,0.002388116,0.000259244,0.0001844212,0.00007902893,0.0001962873,0.0003395809,0.002632405],"genre_scores_gemma":[0.9923071,0.0007165524,0.001108167,0.0001711847,0.00009673116,0.00005795996,0.000365691,0.00004707646,0.005129479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002009832,"threshold_uncertainty_score":0.006723583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00903075629490662,"score_gpt":0.2351846730745192,"score_spread":0.2261539167796126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}