{"id":"W4205243272","doi":"10.1002/alz.055269","title":"Selective targeting of intracellular, misfolded, pathogenic TDP‐43 with rationally designed intrabodies","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada); University of British Columbia","funders":"","keywords":"Transfection; Epitope; Cytoplasm; Biology; Intracellular; Monoclonal antibody; Cell biology; Antibody; Molecular biology; Frontotemporal lobar degeneration; Biochemistry; Gene; Pathology; Medicine; Immunology; Frontotemporal dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581149,0.0005068636,0.0002336604,0.0001539395,0.000128751,0.0003472822,0.0003293548,0.0003974173,0.0004883345],"category_scores_gemma":[0.000168501,0.0001977016,0.0002359054,0.0001111472,0.0002302396,0.0002146111,0.000217142,0.0005913906,0.0003210972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005570819,"about_ca_system_score_gemma":0.000202173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002940811,"about_ca_topic_score_gemma":0.0004534175,"domain_scores_codex":[0.9998657,0.00002517969,0.00001490909,0.00003241274,0.00003148281,0.0000303812],"domain_scores_gemma":[0.9999102,0.00001551974,0.00002612992,0.00001091306,0.00001778875,0.00001951217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000713288,0.00006112607,0.00008513061,0.00003227175,0.000008172612,0.00008149516,0.00001724885,0.0009688452,0.9968557,0.0004200003,0.00007945041,0.001319127],"study_design_scores_gemma":[0.00005455002,0.0002737421,0.0003613103,0.000007146103,0.00002665135,0.0002095552,0.00001271495,0.004300824,0.9918115,0.00009809456,0.002835825,0.00000815541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587979,0.0009928469,0.03721545,0.00018092,0.0000712488,0.0001669794,0.0002042688,0.0001991858,0.002171285],"genre_scores_gemma":[0.9754032,0.0008679419,0.02138205,0.0001581568,0.00001464387,0.0001175674,0.0002627735,0.00005558665,0.001738047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005570819,"threshold_uncertainty_score":0.00404191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02470381952928104,"score_gpt":0.2682377226763918,"score_spread":0.2435339031471108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}