{"id":"W4205246021","doi":"10.7554/elife.67301","title":"Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Universität Konstanz; Universitair Medisch Centrum Utrecht; Amsterdam University Medical Centers; Wageningen University and Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit Leiden; National Institute of Allergy and Infectious Diseases; Health~Holland; U.S. Department of Veterans Affairs","keywords":"Biofilm; Teichoic acid; Monoclonal antibody; In vitro; Staphylococcus aureus; In vivo; Antibiotics; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691999,0.0001714581,0.0002262797,0.00004744549,0.00006862665,0.00004399125,0.00006771107,0.0001795539,0.00001556551],"category_scores_gemma":[0.00005472678,0.0001802776,0.00005155721,0.0001278984,0.00007133832,0.000005873846,0.0001374164,0.0001204567,0.000003075643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001297073,"about_ca_system_score_gemma":0.00007165068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009680312,"about_ca_topic_score_gemma":0.0005806019,"domain_scores_codex":[0.9988319,0.00008019382,0.0002584537,0.0004196059,0.00009089329,0.0003190069],"domain_scores_gemma":[0.9995819,0.000009009224,0.00005716717,0.0002164798,0.00006315226,0.00007227316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005982871,0.00005166472,0.02508179,0.00001320869,0.00001692057,0.00006576372,0.00004947182,0.00001509076,0.9736639,0.000002981283,0.0004442677,0.0005350866],"study_design_scores_gemma":[0.0005872145,0.00003196476,0.04038356,0.0000286478,0.00000370814,0.000005116079,0.0001128181,0.00003097227,0.953086,0.000003445534,0.005503917,0.000222682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973842,0.001523102,0.000001833591,0.0001812313,0.0001598084,0.00009694866,0.00007672763,0.000009815089,0.0005663164],"genre_scores_gemma":[0.9967617,0.0007957887,0.001471792,0.0004312123,0.0001513563,0.000001400051,0.0001288242,0.00001995981,0.0002379526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02057797,"threshold_uncertainty_score":0.7351507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269473594967556,"score_gpt":0.250421437919118,"score_spread":0.2377267019694425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}