{"id":"W4205246021","doi":"10.7554/elife.67301","title":"Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Universität Konstanz; Universitair Medisch Centrum Utrecht; Amsterdam University Medical Centers; Wageningen University and Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit Leiden; National Institute of Allergy and Infectious Diseases; Health~Holland; U.S. Department of Veterans Affairs","keywords":"Biofilm; Teichoic acid; Monoclonal antibody; In vitro; Staphylococcus aureus; In vivo; Antibiotics; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003106671,0.0004034411,0.0001747253,0.0002105791,0.00009721519,0.0002028538,0.0001549357,0.0003778462,0.00234915],"category_scores_gemma":[0.0002868749,0.000105866,0.0001620126,0.0001004228,0.0001196541,0.0001167113,0.0001547774,0.0004255273,0.0005481967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001813188,"about_ca_system_score_gemma":0.0001331339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005140086,"about_ca_topic_score_gemma":0.0007216319,"domain_scores_codex":[0.9997956,0.00005963996,0.0000123261,0.00004525812,0.00004626423,0.00004101466],"domain_scores_gemma":[0.9998591,0.0000569873,0.00001628903,0.00001851635,0.00003054179,0.00001851597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009136563,0.00006256085,0.0006692286,0.00004273075,0.00001000801,0.00003413475,0.00002617722,0.0000505838,0.9931069,0.00008865483,0.000166521,0.005650983],"study_design_scores_gemma":[0.00004933507,0.00141426,0.0127869,0.00002668472,0.00006633696,0.0008635332,0.00004227956,0.001350908,0.9705693,0.0001393865,0.01268175,0.000009483892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701142,0.005200484,0.01895348,0.0003099292,0.00007896725,0.00009939742,0.0003041953,0.0001707015,0.004768541],"genre_scores_gemma":[0.9853122,0.001558283,0.007504778,0.0001809757,0.00002824754,0.00008815592,0.0006639382,0.00001962885,0.004643781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234915,"threshold_uncertainty_score":0.007858634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269473594967556,"score_gpt":0.250421437919118,"score_spread":0.2377267019694425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}