{"id":"W4205249216","doi":"10.1371/journal.pone.0262158","title":"The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishmania major infection","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Leishmania; Innate immune system; Leishmania major; Amastigote; Macrophage; Effector; Inflammation; Flow cytometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001789345,0.0001293259,0.0003564733,0.0002074709,0.0001241549,0.00002560274,0.0001666395,0.00007375633,0.00002939648],"category_scores_gemma":[0.003254034,0.00008781715,0.00007587359,0.0007391588,0.0001067951,0.0001129969,0.0001573036,0.0002929237,0.00002651849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001335963,"about_ca_system_score_gemma":0.0002091813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002099718,"about_ca_topic_score_gemma":0.0008964412,"domain_scores_codex":[0.9975073,0.0005852886,0.0005036754,0.0002255565,0.0009087511,0.0002694834],"domain_scores_gemma":[0.9978113,0.0006982277,0.0001488329,0.0006146215,0.0006683901,0.00005860464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001595018,0.0008920881,0.3199341,0.0001916448,0.000267813,0.00002319289,0.002511664,0.00002972257,0.6718906,0.0005494177,0.0001286182,0.001986121],"study_design_scores_gemma":[0.000681363,0.0003134142,0.8149607,0.0002852032,0.00005654511,0.000005745928,0.0008392934,0.0002807083,0.1813397,0.0004219799,0.0007463919,0.00006905941],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992406,0.0005549141,0.000006772612,0.004414015,0.00002456016,0.0007746021,0.000006268546,0.0000223385,0.001790535],"genre_scores_gemma":[0.9987157,0.0002840748,0.0002130946,0.0001079502,0.00007528724,0.0001180439,0.000006173284,0.00002141654,0.0004582347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4950266,"threshold_uncertainty_score":0.3895617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03173834769016924,"score_gpt":0.2757145082023655,"score_spread":0.2439761605121963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}