{"id":"W4205253993","doi":"10.1056/nejmoa1900750","title":"Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1180,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Research and Development","keywords":"Ustekinumab; Medicine; Maintenance therapy; Randomization; Placebo; Ulcerative colitis; Internal medicine; Gastroenterology; Surgery; Randomized controlled trial; Chemotherapy; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003373641,0.00007754658,0.0001340314,0.00003454752,0.00002419951,0.00000598753,0.00005641039,0.00005215178,0.0000582297],"category_scores_gemma":[0.0001522663,0.00005239214,0.00003294943,0.00002047023,0.00004796234,0.0000061393,0.000008498124,0.00007291873,0.000001535311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001050133,"about_ca_system_score_gemma":0.0001192299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008397616,"about_ca_topic_score_gemma":0.00001417487,"domain_scores_codex":[0.9994784,0.00004567614,0.0001781584,0.00009380497,0.0001052025,0.0000987668],"domain_scores_gemma":[0.9994581,0.00002122031,0.0001486207,0.00008301139,0.0001770604,0.0001119422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04936836,0.0001216478,0.02834246,0.0001405837,0.0006102018,0.0002642004,0.002696542,0.0001077039,0.4171624,0.002867254,0.0688767,0.429442],"study_design_scores_gemma":[0.1539259,0.009096745,0.2879097,0.0003190883,0.00008684256,0.001786642,0.0009339635,0.00005275435,0.01660886,0.003908841,0.5250481,0.0003226485],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965916,0.0004900624,0.0004515831,0.001222391,0.0004370187,0.0001916588,0.000002945768,0.000001539317,0.0006112354],"genre_scores_gemma":[0.9948936,0.0005884473,0.0001756728,0.0006025711,0.002413233,0.000002089719,0.00000771709,0.000009632392,0.001307004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4561714,"threshold_uncertainty_score":0.2136489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008702714478102707,"score_gpt":0.2584245139701914,"score_spread":0.2497217994920888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}