{"id":"W4205253993","doi":"10.1056/nejmoa1900750","title":"Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1180,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Research and Development","keywords":"Ustekinumab; Medicine; Maintenance therapy; Randomization; Placebo; Ulcerative colitis; Internal medicine; Gastroenterology; Surgery; Randomized controlled trial; Chemotherapy; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001635098,0.000342756,0.001424748,0.0003804559,0.0002210053,0.0003747236,0.0005385479,0.0006406915,0.002012118],"category_scores_gemma":[0.001338982,0.0001545547,0.0004702767,0.0003444384,0.0004234944,0.0004619155,0.0002987512,0.001468016,0.0003314505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003003285,"about_ca_system_score_gemma":0.0003367054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001910449,"about_ca_topic_score_gemma":0.0004275201,"domain_scores_codex":[0.9991927,0.0003812213,0.00008356069,0.00007601209,0.000144356,0.0001220741],"domain_scores_gemma":[0.9989111,0.0003779862,0.0002620212,0.00008942574,0.00004919145,0.0003103338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3448837,0.0166362,0.02233788,0.001936137,0.001092751,0.000269333,0.000280383,0.001349389,0.03722892,0.0003574278,0.001755348,0.5718725],"study_design_scores_gemma":[0.2396925,0.6433367,0.08537652,0.0005199661,0.001506565,0.001234338,0.0001266667,0.001830464,0.01561114,0.0003717253,0.0103372,0.00005622895],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795736,0.01757921,0.0003423739,0.0002806293,0.00008878323,0.0005307187,0.0002165561,0.00005464041,0.001333516],"genre_scores_gemma":[0.9928609,0.004547207,0.0007929795,0.0002305449,0.0001944761,0.0005284871,0.0002551391,0.000005463052,0.000584949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012118,"threshold_uncertainty_score":0.008647382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008702714478102707,"score_gpt":0.2584245139701914,"score_spread":0.2497217994920888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}