{"id":"W4205255113","doi":"10.1016/j.cellsig.2021.110226","title":"A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in rat striatal neurons","year":2021,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"BRD4; Bromodomain; Transcription factor; Gene knockdown; Transcription (linguistics); BET inhibitor; Histone; Promoter; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002818128,0.0001405202,0.0001528431,0.00006933358,0.00006158993,0.00004699615,0.0000740988,0.0001388794,0.00001004758],"category_scores_gemma":[0.0001032234,0.0001576836,0.00006008542,0.0001144036,0.00001627665,0.00001270754,0.00003832961,0.0001286052,8.462908e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002255451,"about_ca_system_score_gemma":0.00008442746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002733502,"about_ca_topic_score_gemma":0.0003208226,"domain_scores_codex":[0.9988581,0.00009802701,0.0002989268,0.0004055199,0.0001090164,0.0002304326],"domain_scores_gemma":[0.9996577,0.00001456502,0.0000671111,0.0001539555,0.00004890444,0.0000577506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000559281,0.00005380759,0.0003546392,0.00003987411,0.000006522558,0.000008240714,0.00009546236,0.0002608391,0.9975054,0.00003920395,0.000007527191,0.001572596],"study_design_scores_gemma":[0.001340079,0.000127052,0.000128468,0.00006874613,0.000007629636,0.000003475187,0.0002674704,0.003007318,0.9939719,0.00009578944,0.0008077936,0.0001743066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876006,0.001391475,0.01014292,0.0001304984,0.0000932712,0.0005672069,0.00001055602,0.000009099877,0.00005435605],"genre_scores_gemma":[0.997851,0.0000464008,0.001359589,0.00004933965,0.0001502171,0.00009532364,0.0002159152,0.00002437334,0.0002078402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01025038,"threshold_uncertainty_score":0.6430149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662642497520007,"score_gpt":0.2301564992175784,"score_spread":0.2135300742423783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}