{"id":"W4205272218","doi":"10.1038/s42255-021-00515-3","title":"Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity","year":2022,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; American Diabetes Association; American Heart Association","keywords":"Leptin; HDAC6; Endocrinology; Internal medicine; Adipose tissue; Histone deacetylase; Adipokine; Obesity; Sirtuin; Melanocortin; Medicine; Chemistry; Acetylation; Hormone; Histone; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009542166,0.0002102816,0.0002364595,0.000145685,0.0005410833,0.00002932342,0.0001153485,0.00028058,0.00005331347],"category_scores_gemma":[0.0003447664,0.0002242166,0.000102203,0.00023237,0.0001977205,0.000009910547,0.0004866036,0.0009939569,0.000008209477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007793485,"about_ca_system_score_gemma":0.0001342004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009553954,"about_ca_topic_score_gemma":0.00009590843,"domain_scores_codex":[0.9977564,0.0005890913,0.0001966508,0.0006095008,0.000504276,0.0003440559],"domain_scores_gemma":[0.9992115,0.00003169058,0.00009478077,0.0003891875,0.000121568,0.0001512662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557799,0.0001218518,0.00007485496,0.000009758111,0.00002439058,0.00005994192,0.0001154423,0.000027037,0.9715252,0.0002977556,0.02566667,0.001921343],"study_design_scores_gemma":[0.0005510939,0.00008082906,0.00406059,0.000004371335,0.00002069854,0.0001402636,0.0000899439,0.00002212099,0.789399,0.00003878184,0.2053558,0.0002365176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847266,0.01305377,0.00002687151,0.0006491637,0.0004983778,0.0002551126,0.0001296492,0.00003607121,0.0006243975],"genre_scores_gemma":[0.9962807,0.0001731379,0.0004807433,0.0004147984,0.0005991885,0.00005425701,0.0002559943,0.00003661875,0.001704536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1821261,"threshold_uncertainty_score":0.9143288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005871267498082921,"score_gpt":0.2764409063989239,"score_spread":0.270569638900841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}