{"id":"W4205272218","doi":"10.1038/s42255-021-00515-3","title":"Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity","year":2022,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; American Diabetes Association; American Heart Association","keywords":"Leptin; HDAC6; Endocrinology; Internal medicine; Adipose tissue; Histone deacetylase; Adipokine; Obesity; Sirtuin; Melanocortin; Medicine; Chemistry; Acetylation; Hormone; Histone; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137438,0.000747843,0.0007757402,0.0006447896,0.0002675805,0.0005945493,0.0007782232,0.000609945,0.005185522],"category_scores_gemma":[0.0002409613,0.0004345081,0.0006400802,0.000325241,0.0006306349,0.0003705872,0.0003474345,0.002489935,0.001005841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003906839,"about_ca_system_score_gemma":0.0004890984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171108,"about_ca_topic_score_gemma":0.002104434,"domain_scores_codex":[0.9997696,0.00002581591,0.00002399593,0.00003946778,0.00006013558,0.00008098665],"domain_scores_gemma":[0.9996878,0.00002610947,0.00008225488,0.00003529549,0.0000204203,0.0001481869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008249964,0.0009263838,0.0003746499,0.0001233545,0.0001566158,0.0001298573,0.00002178152,0.000305069,0.9790893,0.0003772046,0.0008409732,0.009404748],"study_design_scores_gemma":[0.002187839,0.006942547,0.01146594,0.00003479833,0.0003214634,0.0005293694,0.0001830718,0.001722717,0.9626125,0.0006172818,0.01332645,0.00005603613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866188,0.003181051,0.002991352,0.001208666,0.0006500812,0.00004670276,0.001507931,0.0009665356,0.002828913],"genre_scores_gemma":[0.9859096,0.002659176,0.001772344,0.0005054472,0.0001252254,0.0000598063,0.001675713,0.0002039743,0.007088668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005185522,"threshold_uncertainty_score":0.01734728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005871267498082921,"score_gpt":0.2764409063989239,"score_spread":0.270569638900841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}