{"id":"W4205274612","doi":"10.1016/j.xcrm.2021.100506","title":"MEK inhibition invigorates chemoimmunotherapy by tumor mitophagy-induced CXCL10 expression","year":2022,"lang":"en","type":"letter","venue":"Cell Reports Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute, Cairo University; Takeda Pharmaceuticals U.S.A.; Sanofi; Astellas Pharma US; Janssen Pharmaceuticals; AstraZeneca; Eli Lilly and Company","keywords":"Cancer research; Chemoimmunotherapy; Medicine; Cancer; MEK inhibitor; MAPK/ERK pathway; Internal medicine; Immunotherapy; Biology; Kinase; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238812,0.0005808477,0.0006770694,0.0005908794,0.0002376369,0.0004937556,0.0002259547,0.0004379301,0.003403222],"category_scores_gemma":[0.0002103599,0.000144877,0.0007506841,0.0003540129,0.0002278957,0.0004129477,0.0003338719,0.001131906,0.0007875961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000438973,"about_ca_system_score_gemma":0.0004331314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009241628,"about_ca_topic_score_gemma":0.002306158,"domain_scores_codex":[0.9998119,0.00003032226,0.00001556054,0.00003242934,0.00006071155,0.00004900197],"domain_scores_gemma":[0.9998688,0.00003594724,0.00001582515,0.00001297558,0.00004082258,0.00002568301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002628757,0.0009175603,0.00109159,0.004238389,0.0003268313,0.0003402268,0.0001433071,0.0003649185,0.8645059,0.0006894476,0.01180288,0.1129502],"study_design_scores_gemma":[0.000297017,0.003229856,0.009382173,0.000143717,0.0004510873,0.0008749351,0.0001328514,0.001190994,0.8778066,0.0003011665,0.1061389,0.00005068454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7795801,0.1583214,0.01296389,0.008634136,0.003176777,0.000798095,0.004585261,0.001338501,0.03060187],"genre_scores_gemma":[0.860667,0.08411513,0.00712303,0.003531941,0.0003404169,0.0004999435,0.004738846,0.0001905289,0.03879321],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.003403222,"threshold_uncertainty_score":0.0113849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590015017601759,"score_gpt":0.255251365299526,"score_spread":0.2393512151235084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}