{"id":"W4205275020","doi":"10.1089/crispr.2021.0128","title":"High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells","year":2022,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"CRISPR; Genome editing; Cas9; Adeno-associated virus; Biology; Genetic enhancement; Computational biology; Genome; Gene; Recombinant DNA; Genetics; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001322256,0.0001710243,0.0002327525,0.00009476096,0.0003495554,0.00004875975,0.0002312971,0.00005452228,0.00002318598],"category_scores_gemma":[0.00004285403,0.0001465545,0.00006245157,0.0001240954,0.00007231658,0.00000762061,0.0003087873,0.0003787902,3.711499e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004367367,"about_ca_system_score_gemma":0.00005627384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004487081,"about_ca_topic_score_gemma":0.00001440318,"domain_scores_codex":[0.9984687,0.0004202745,0.00038848,0.0002352538,0.0001951404,0.0002921692],"domain_scores_gemma":[0.9993928,0.00004730164,0.0001786093,0.000245738,0.00005017916,0.00008536284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00023266,0.00009093081,0.001026872,0.00001986502,0.00004054171,0.00003542724,0.0009462486,0.0001592759,0.9967002,0.00001547336,0.0004777603,0.0002547348],"study_design_scores_gemma":[0.001476975,0.0005670402,0.01288637,0.00004129735,0.0000516119,0.0003531921,0.002596851,0.0001691804,0.9808674,0.0001871389,0.0005699562,0.0002329644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996908,0.001892409,0.0002778784,0.0004083889,0.0002960203,0.0001844642,0.00001497399,0.00000727187,0.00001056649],"genre_scores_gemma":[0.9994622,0.0001601477,0.00008601705,0.00006698426,0.00006831547,0.00001510695,0.000004728146,0.00003160728,0.0001049202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01583279,"threshold_uncertainty_score":0.5976318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009691495959859733,"score_gpt":0.2812805686757335,"score_spread":0.2715890727158737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}