{"id":"W4205290014","doi":"10.1001/jamaneurol.2021.4781","title":"Association of Essential Tremor With Novel Risk Loci","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université Laval; Hôpital de l'Enfant-Jésus; McGill University; McGill University Health Centre; Saskatchewan Health Authority; Centre hospitalier universitaire de Québec; Montreal Children's Hospital; Université de Montréal; University of Saskatchewan; Université du Québec à Chicoutimi; University of British Columbia; Montreal Neurological Institute and Hospital","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Université de Montréal; Centre Hospitalier Universitaire de Québec; Faculté de Médecine, Université Laval; Children's Hospital Foundation; Università degli Studi di Genova; Sage Therapeutics; Università degli Studi di Salerno; McGill University; McGill University Health Centre; Jazz Pharmaceuticals; Boston Scientific Corporation; bluebird bio; Virginia Commonwealth University; University of Texas Southwestern Medical Center; Université Laval","keywords":"Essential tremor; Heritability; Association (psychology); Genetic association; Genetic variation; Missing heritability problem; Variation (astronomy); Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002022662,0.0006698942,0.000646389,0.001240912,0.0003908862,0.001048882,0.0007085348,0.001054583,0.003378436],"category_scores_gemma":[0.006554813,0.0002658042,0.001526645,0.002022899,0.0005015504,0.0003484703,0.0005145648,0.0006026234,0.0002388933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053393,"about_ca_system_score_gemma":0.0005263998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00244811,"about_ca_topic_score_gemma":0.003437161,"domain_scores_codex":[0.9981072,0.0004173341,0.0003653871,0.000649858,0.0003533909,0.0001067975],"domain_scores_gemma":[0.9943225,0.002682734,0.002095024,0.0003680711,0.0003360978,0.0001955463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001985365,0.0001319257,0.9517564,0.0004905032,0.007951918,0.003700186,0.0002335957,0.001251285,0.007075898,0.0005805354,0.001126916,0.02371552],"study_design_scores_gemma":[0.0005725108,0.0003523425,0.9767278,0.0001862505,0.006058359,0.005914816,0.0001253607,0.004083576,0.001997518,0.001935928,0.001999402,0.00004610682],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849342,0.007366344,0.003803941,0.0005734767,0.00008358102,0.00002896568,0.002047768,0.00009143198,0.001070225],"genre_scores_gemma":[0.9969049,0.0007112686,0.001137532,0.00008228877,0.00006811772,0.0000135227,0.0008554774,0.00001195528,0.0002149918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003378436,"threshold_uncertainty_score":0.01130193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008590490051785126,"score_gpt":0.2329347161775542,"score_spread":0.2243442261257691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}