{"id":"W4205295223","doi":"10.1101/2022.01.14.476381","title":"Mitochondrial and redox modifications in early stages of Huntington’s disease","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Universidade de Coimbra; Fundação para a Ciência e a Tecnologia; Santa Casa da Misericórdia de Lisboa; Fundação Luso-Americana para o Desenvolvimento; European Regional Development Fund; Programa Operacional Regional do Centro","keywords":"Mitochondrion; In vivo; Huntington's disease; Ex vivo; Reactive oxygen species; Biology; Striatum; Pathology; Molecular biology; Chemistry; Cell biology; Endocrinology; Medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179728,0.0002038331,0.0001341845,0.0003196659,0.000146568,0.0001970589,0.0001014855,0.0002930407,0.0006692188],"category_scores_gemma":[0.00007779124,0.0001502767,0.0001206755,0.0001302937,0.0001264809,0.0001913769,0.0001387771,0.000242189,0.0001238945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453013,"about_ca_system_score_gemma":0.000064015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008142864,"about_ca_topic_score_gemma":0.0009754736,"domain_scores_codex":[0.9999685,0.000005091958,0.0000034875,0.000008920315,0.000006700731,0.000007325101],"domain_scores_gemma":[0.9999385,0.000005904214,0.00002190625,0.000003349602,0.00001196795,0.00001834787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008072091,0.00004653834,0.01442909,0.00003866152,0.00001861832,0.0005940687,0.0001088333,0.0000421777,0.9821361,0.00004812987,0.00004031573,0.001690231],"study_design_scores_gemma":[0.00003338809,0.001212443,0.7615146,0.00002328647,0.00005081582,0.003417488,0.0003816994,0.0005261695,0.231429,0.0002203229,0.00117792,0.0000127756],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985533,0.0007676648,0.0002741616,0.00001055143,0.000002598201,0.000005103815,0.000106687,0.000008236029,0.0002716257],"genre_scores_gemma":[0.9987292,0.0003793813,0.0002168906,0.000009112312,0.00000207563,0.000005452815,0.0001807792,0.000001866621,0.0004752208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008142864,"threshold_uncertainty_score":0.00223875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322819300082802,"score_gpt":0.2460437858436783,"score_spread":0.2228155928428503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}