{"id":"W4205314496","doi":"10.1200/jco.2021.39.15_suppl.4030","title":"LEAP-005: A phase 2 multicohort study of lenvatinib plus pembrolizumab in patients with previously treated selected solid tumors—Results from the gastric cancer cohort.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Lenvatinib; Medicine; Pembrolizumab; Internal medicine; Cancer; Response Evaluation Criteria in Solid Tumors; Oncology; Cohort; Adverse effect; Phases of clinical research; Gastroenterology; Surgery; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005054082,0.002102691,0.001716119,0.000591802,0.000617879,0.0013277,0.001063484,0.001175092,0.004166248],"category_scores_gemma":[0.001661051,0.0008534188,0.001988218,0.0005230862,0.001100857,0.001278096,0.0008411895,0.002684114,0.001095796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001322719,"about_ca_system_score_gemma":0.002008202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001106663,"about_ca_topic_score_gemma":0.001911557,"domain_scores_codex":[0.9988176,0.0006549352,0.00005948641,0.000200027,0.0001071841,0.0001607101],"domain_scores_gemma":[0.9985772,0.0001858977,0.000301713,0.0001706541,0.00008924124,0.0006751161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8135929,0.08973885,0.02845849,0.0005654653,0.004455753,0.0003553949,0.0003883952,0.001441597,0.01768137,0.0002117052,0.003884957,0.03922519],"study_design_scores_gemma":[0.5750218,0.3619906,0.05290062,0.00003764325,0.001847339,0.0005361121,0.0001675712,0.00124874,0.002195653,0.0002012971,0.003787628,0.00006493839],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939981,0.0009400273,0.0003866518,0.000198881,0.00007638309,0.002410709,0.001281221,0.00005521099,0.000652759],"genre_scores_gemma":[0.9876581,0.0007138847,0.001539271,0.0007725024,0.0001870683,0.003409494,0.004129432,0.0000319607,0.001558231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005054082,"threshold_uncertainty_score":0.02672887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06555682777850554,"score_gpt":0.4240821736288863,"score_spread":0.3585253458503808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}