{"id":"W4205317232","doi":"10.1093/hmg/ddab372","title":"Systematic identification of genomic elements that regulate<i>FCGR2A</i>expression and harbor variants linked with autoimmune disease","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Human Genome Research Institute; National Institutes of Health","keywords":"Biology; Enhancer; Transcription factor; CTCF; Genetics; DNA binding site; Gene; Genome-wide association study; Immune system; Gene expression; Computational biology; Promoter; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148255,0.0002408437,0.0003387798,0.0006775693,0.0001600074,0.0002465521,0.0002437873,0.0003448889,0.001200077],"category_scores_gemma":[0.0004097342,0.0001426886,0.0004004467,0.0005099003,0.0002473892,0.00006576328,0.0002632602,0.0003684431,0.000250381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207405,"about_ca_system_score_gemma":0.0002069485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104632,"about_ca_topic_score_gemma":0.001963364,"domain_scores_codex":[0.9997293,0.00003700081,0.00002186776,0.0001147506,0.00005966821,0.00003744161],"domain_scores_gemma":[0.9995943,0.0001238554,0.0001606997,0.00004884854,0.0000282351,0.00004399265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006398489,0.00004644702,0.03026223,0.0001422957,0.0001310604,0.000669696,0.0001039423,0.0003332227,0.9602551,0.0001963068,0.0001686388,0.007051164],"study_design_scores_gemma":[0.00009237862,0.0007143646,0.7111214,0.00006977381,0.0005011646,0.008032569,0.0001628367,0.002489139,0.2683847,0.000222578,0.008174254,0.00003485197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914739,0.0009979509,0.004447377,0.00005492032,0.00001365916,0.00005059168,0.002227346,0.00008533542,0.0006488414],"genre_scores_gemma":[0.9921726,0.0003276897,0.004776211,0.00008769428,0.00001316926,0.00003413463,0.002043646,0.00004715023,0.0004978163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200077,"threshold_uncertainty_score":0.004014671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908475036512739,"score_gpt":0.2839720282647676,"score_spread":0.2648872778996402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}