{"id":"W4205325712","doi":"10.1038/s41467-022-27974-w","title":"In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Fondation Leducq; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Conseil Régional des Pays de la Loire; AFM-Téléthon; Agence Nationale de la Recherche","keywords":"In vivo; Sodium channel; Ion channel; HEK 293 cells; Chemistry; Biophysics; Peptide; Ex vivo; Voltage-gated ion channel; Cell biology; Biology; Biochemistry; Sodium; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003249118,0.0001234776,0.0001867589,0.00007999295,0.0002170348,0.000007845279,0.0007706198,0.0001739915,0.00009324413],"category_scores_gemma":[0.0001173348,0.0001399039,0.00006914526,0.000335324,0.00007673001,0.000008973879,0.0005764085,0.0006505196,7.523167e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007726048,"about_ca_system_score_gemma":0.0001155405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003095182,"about_ca_topic_score_gemma":0.0001525993,"domain_scores_codex":[0.998903,0.0002524445,0.0002862167,0.0002162084,0.000163278,0.0001788722],"domain_scores_gemma":[0.9985318,0.00004616344,0.0002046915,0.001084445,0.00009470496,0.00003822139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004891966,0.0004123481,0.003712103,0.000004636202,0.00004399938,9.032094e-8,0.0001013754,0.0002956705,0.9818019,0.000066409,0.01345702,0.00005556621],"study_design_scores_gemma":[0.001621166,0.0001731588,0.00009443355,0.00001093785,0.00002603566,0.000007879795,0.0003746971,0.003200464,0.7134944,0.00001712048,0.2807512,0.0002284616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887199,0.006965965,0.001024299,0.0009330468,0.0003580624,0.0007028041,0.0005610302,0.00001816587,0.0007167326],"genre_scores_gemma":[0.9981574,0.0001856466,0.000489331,0.00032611,0.00005215365,0.00005637803,0.0003790767,0.00002374231,0.0003300976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2683074,"threshold_uncertainty_score":0.5705118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333228970548773,"score_gpt":0.289359380539798,"score_spread":0.2760270908343103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}