{"id":"W4205331651","doi":"10.1126/science.abn7760","title":"SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":693,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; University of British Columbia","funders":"","keywords":"Neutralization; Antibody; Chemistry; Affinities; Binding affinities; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike (software development); Virology; Biophysics; Coronavirus disease 2019 (COVID-19); Biology; Genetics; Stereochemistry; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007127664,0.0001311366,0.0002489922,0.0002944667,0.0004432905,0.00005268982,0.000442261,0.00003991517,0.0000470197],"category_scores_gemma":[0.0001774134,0.0001095058,0.00004311822,0.001134151,0.0006723919,0.000155659,0.0005478486,0.0003088638,0.00000636868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302572,"about_ca_system_score_gemma":0.0005930227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000168583,"about_ca_topic_score_gemma":0.00002216062,"domain_scores_codex":[0.997732,0.00006162874,0.0002166026,0.0005053165,0.001076781,0.0004076845],"domain_scores_gemma":[0.9992343,0.00003033313,0.00008838401,0.000451858,0.0001535162,0.00004156615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001377273,0.00006531448,0.004305468,0.00009863411,0.000005361094,0.00004474001,0.0005221925,7.695741e-7,0.992175,0.0003034326,0.00009693815,0.002244469],"study_design_scores_gemma":[0.0009233526,0.0005187478,0.02706505,0.00004689256,0.00001234703,0.0001806719,0.0003183004,0.00123834,0.9491948,0.0005596878,0.01981562,0.0001262248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978902,0.0002367411,0.0001152148,0.0003188698,0.0001106431,0.0006569027,0.00003221235,0.00003046291,0.000608722],"genre_scores_gemma":[0.9948645,0.000001576284,0.0007402921,0.004302055,0.00004459947,0.000009347045,0.000003610141,0.00001207525,0.00002195811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04298019,"threshold_uncertainty_score":0.4465519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04757664389475095,"score_gpt":0.372307182509606,"score_spread":0.324730538614855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}