{"id":"W4205341592","doi":"10.1021/acs.jmedchem.1c01708","title":"Size-Reduced Macrocyclic Analogues of [Pyr<sup>1</sup>]-apelin-13 Showing Negative Gα<sub>12</sub> Bias Still Produce Prolonged Cardiac Effects","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canada Foundation for Innovation; Université de Sherbrooke; Canadian Institutes of Health Research; Mitacs; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Potency; Agonist; EC50; Apelin; Stereochemistry; In vivo; Metabolic stability; Intrinsic activity; Pharmacology; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003967811,0.0005154497,0.001724627,0.0003213954,0.0002171294,0.00002187226,0.00071902,0.0003618925,0.0004071851],"category_scores_gemma":[0.01637914,0.0004092922,0.0006782255,0.00109823,0.0006894447,0.0001474921,0.0003870282,0.004053834,0.00001183988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007401333,"about_ca_system_score_gemma":0.001759049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003602319,"about_ca_topic_score_gemma":8.160019e-7,"domain_scores_codex":[0.9919352,0.0005199089,0.00173109,0.0006306448,0.004270278,0.0009128674],"domain_scores_gemma":[0.9935887,0.002563121,0.001184671,0.0006047774,0.000936801,0.001121918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003196445,0.0006225992,0.003353687,0.001625915,0.001103914,0.001660129,0.001979716,0.0001259713,0.9695712,6.350121e-7,0.005673117,0.01108667],"study_design_scores_gemma":[0.006506434,0.002531749,0.01259315,0.001883887,0.001211492,0.001469663,0.004011662,0.0005714835,0.967386,0.00008995504,0.001348216,0.0003962939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990335,0.003870457,0.00001869196,0.003993533,0.0003643012,0.0007421189,0.0000400247,0.00004458956,0.0005912912],"genre_scores_gemma":[0.9962356,0.0005000434,0.0002589441,0.0003816015,0.002020017,0.00004728885,0.00004464032,0.00008413094,0.000427741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01241133,"threshold_uncertainty_score":0.9998359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333881699511839,"score_gpt":0.2884313110138776,"score_spread":0.2650924940187593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}