{"id":"W4205347208","doi":"10.1016/s2213-2600(21)00502-6","title":"Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial","year":2022,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Cegep regional de Lanaudiere","funders":"Mylan; UK Research and Innovation; Sunovion; Grifols; Boston Scientific Corporation; Sanofi; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; AstraZeneca; Amgen","keywords":"Pulmonary disease; Haemophilus influenzae; Clinical trial; MEDLINE; Respiratory tract infections; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003517229,0.002420369,0.00427446,0.0004778545,0.0006064328,0.001369892,0.00148059,0.003298731,0.006621256],"category_scores_gemma":[0.003277047,0.0008457997,0.003200864,0.0004579249,0.00142124,0.001388418,0.0006644166,0.003597573,0.001072194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009837947,"about_ca_system_score_gemma":0.001314903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421212,"about_ca_topic_score_gemma":0.002977561,"domain_scores_codex":[0.9984554,0.0008319242,0.0001030174,0.0002663457,0.0001486243,0.0001946056],"domain_scores_gemma":[0.9987061,0.0004549836,0.0003082786,0.0001158148,0.000120751,0.0002941548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9794078,0.003931241,0.0001927741,0.001467452,0.001242295,0.00002174352,0.00006253204,0.0001179018,0.002432055,0.00008590845,0.0006402252,0.01039804],"study_design_scores_gemma":[0.9710456,0.02708321,0.0007834314,0.00004756759,0.0003124795,0.00001590964,0.00001389801,0.00009041036,0.0001753124,0.00006227106,0.0003603523,0.000009753429],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589019,0.0231167,0.001820836,0.001379,0.002239317,0.008598905,0.001611505,0.000170513,0.002161261],"genre_scores_gemma":[0.9665313,0.008868136,0.004542244,0.002405462,0.001365632,0.01000921,0.001427211,0.00005359574,0.004797435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006621256,"threshold_uncertainty_score":0.02215028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06649055409681909,"score_gpt":0.3524334322891045,"score_spread":0.2859428781922854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}