{"id":"W4205370642","doi":"10.1002/alz.058332","title":"Gelsolin Amyloidosis: aggregation propensities of wild and mutant peptides and their inhibition","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"","keywords":"Gelsolin; Fibril; Mutant; Thioflavin; Amyloid (mycology); Cleavage (geology); Amyloidosis; Protein aggregation; Chemistry; Peptide; Biophysics; Cell biology; Biochemistry; Amyloid disease; Biology; Actin; Amyloid fibril; Alzheimer's disease; Pathology; Medicine; Amyloid β","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605578,0.0002702418,0.0001290793,0.0002973092,0.00009737551,0.0001424862,0.0001487109,0.0002316217,0.0007321848],"category_scores_gemma":[0.0003063491,0.0001026875,0.0001892681,0.0002391657,0.0001355629,0.0001805344,0.0000803986,0.0003955839,0.0001671201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001554194,"about_ca_system_score_gemma":0.00008831682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006887735,"about_ca_topic_score_gemma":0.0004317517,"domain_scores_codex":[0.9998388,0.00004943475,0.00001654272,0.00002088656,0.0000463265,0.00002784938],"domain_scores_gemma":[0.9997299,0.0001136412,0.0000540095,0.00001668087,0.00004654054,0.00003910983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000381587,0.0001129137,0.0002448711,0.00006156203,0.00001298874,0.00007361409,0.00003054534,0.000306086,0.9972543,0.000106111,0.0001026622,0.001312841],"study_design_scores_gemma":[0.00001440941,0.0007171904,0.002192246,0.000006552069,0.00001786883,0.0001315599,0.00001153889,0.001676122,0.9943212,0.00003998744,0.0008625636,0.000008733173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943888,0.002721335,0.001180131,0.00005319544,0.00002558911,0.00002299286,0.0003938209,0.00003340818,0.001180699],"genre_scores_gemma":[0.9958996,0.001102788,0.001585997,0.00002978467,0.00001471967,0.00003120168,0.0004158697,0.00001375816,0.0009061876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007321848,"threshold_uncertainty_score":0.002449393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02693327162085837,"score_gpt":0.2731181074934554,"score_spread":0.2461848358725971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}