{"id":"W4205375279","doi":"10.7150/jca.57663","title":"Oncogene or Tumor Suppressor: The Coordinative Role of Lysine Methyltransferase SET7/9 in Cancer Development and the Related Mechanisms","year":2022,"lang":"en","type":"review","venue":"Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Southeast University; National Natural Science Foundation of China; Saskatchewan Health Research Foundation","keywords":"Epigenetics; Histone; Cancer; Histone H3; Suppressor; Methylation; Lysine; Methyltransferase; Histone methyltransferase; Cancer research; Biology; Histone methylation; Cell biology; Chemistry; DNA methylation; Biochemistry; Genetics; Gene expression; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003784398,0.0006091688,0.0008358239,0.001614827,0.0002296304,0.0005823993,0.0007210919,0.0008158999,0.002227233],"category_scores_gemma":[0.0004534549,0.0001926653,0.0003225558,0.001502839,0.0004133719,0.001020626,0.00052255,0.001397777,0.001305806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005737036,"about_ca_system_score_gemma":0.0009397505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006681596,"about_ca_topic_score_gemma":0.001326283,"domain_scores_codex":[0.9998931,0.00001739206,0.00001516436,0.00002086771,0.00004056994,0.00001302202],"domain_scores_gemma":[0.9998292,0.00006741673,0.0000237994,0.00000522294,0.00004927913,0.0000251173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008119071,0.00004901829,0.0002878812,0.01381808,0.00009895321,0.0004500085,0.00005914133,0.0003883177,0.004119148,0.005354066,0.03694937,0.9383449],"study_design_scores_gemma":[0.00001155245,0.00006450072,0.0007350548,0.001155485,0.00007146283,0.002127226,0.00003525626,0.00007015102,0.0007626555,0.001585373,0.9933667,0.00001469534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000131004,0.9981772,0.0001377337,0.0003816698,0.0002686118,0.000003232308,0.00001585803,0.000006610076,0.0008781822],"genre_scores_gemma":[0.0006349148,0.9983314,0.0001476023,0.0001809516,0.0001712882,0.000003839339,0.0000258343,0.000001093495,0.0005031348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002227233,"threshold_uncertainty_score":0.007450879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297839439178534,"score_gpt":0.3452094753914336,"score_spread":0.3154255314735802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}