{"id":"W4205375279","doi":"10.7150/jca.57663","title":"Oncogene or Tumor Suppressor: The Coordinative Role of Lysine Methyltransferase SET7/9 in Cancer Development and the Related Mechanisms","year":2022,"lang":"en","type":"review","venue":"Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Southeast University; National Natural Science Foundation of China; Saskatchewan Health Research Foundation","keywords":"Epigenetics; Histone; Cancer; Histone H3; Suppressor; Methylation; Lysine; Methyltransferase; Histone methyltransferase; Cancer research; Biology; Histone methylation; Cell biology; Chemistry; DNA methylation; Biochemistry; Genetics; Gene expression; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001200767,0.0002165218,0.0008126255,0.00009259301,0.00007985329,0.0000142387,0.0002950394,0.000117344,0.0001788623],"category_scores_gemma":[0.00009724709,0.0001048217,0.0002285774,0.0002337908,0.00009361965,0.000003859501,0.00009134562,0.0003664296,1.247508e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001003062,"about_ca_system_score_gemma":0.001030643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008415529,"about_ca_topic_score_gemma":0.0003343546,"domain_scores_codex":[0.9980555,0.0004852092,0.0008522221,0.0001790957,0.0002806759,0.0001473252],"domain_scores_gemma":[0.9986345,0.000158067,0.0008586045,0.000172724,0.0001319105,0.00004415113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005900768,0.00008615915,0.00001848002,0.000927666,0.001415486,0.00001730366,0.0008927485,0.0004038895,0.0101741,0.0001500482,0.00008122268,0.9852428],"study_design_scores_gemma":[0.00112828,0.0001619809,0.00001505008,0.000757954,0.000609184,0.00002122104,0.0001663035,0.00001119859,0.04704124,0.0002328987,0.9496965,0.0001581555],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006044645,0.9929759,0.00009912557,0.000146142,0.0002107428,0.0003880981,0.00006563877,7.777721e-7,0.00006891708],"genre_scores_gemma":[0.004627651,0.9946754,0.0002170858,0.00004243124,0.00009088114,0.0001259109,0.00001772449,0.00002860744,0.0001743127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9850847,"threshold_uncertainty_score":0.4274504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297839439178534,"score_gpt":0.3452094753914336,"score_spread":0.3154255314735802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}