{"id":"W4205382183","doi":"10.1101/2022.01.05.475129","title":"Treatment of wound infections in a mouse model using Zn <sup>2+</sup> -releasing phage bound to gold nanorods","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Chemistry; California NanoSystems Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Science Foundation","keywords":"Phage therapy; Antibiotics; Antimicrobial; Microbiology; Photothermal therapy; In vivo; Antibiotic resistance; Bacteria; Pathogen; Polymyxin; Bacteriophage; Nanomaterials; Chemistry; Biology; Materials science; Nanotechnology; Escherichia coli; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002494353,0.0008327624,0.0003993677,0.0003780302,0.000142255,0.0002213803,0.0002798255,0.0005912419,0.0009332658],"category_scores_gemma":[0.00007526673,0.0002677132,0.0003584158,0.0001248926,0.0003513058,0.0002306602,0.0001562323,0.0007808342,0.0002141835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857365,"about_ca_system_score_gemma":0.000165487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003500111,"about_ca_topic_score_gemma":0.0005809728,"domain_scores_codex":[0.9998112,0.00003174847,0.00001308458,0.00005378885,0.00004900006,0.00004111383],"domain_scores_gemma":[0.9998769,0.00001753352,0.0000471206,0.00001830052,0.00001083331,0.0000293276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000144816,0.00007286503,0.00003874936,0.00003232041,0.000003369958,0.00001749183,0.00000644337,0.00005619566,0.9988769,0.00003148871,0.00002785215,0.0006915978],"study_design_scores_gemma":[0.00002818372,0.0009693556,0.0005984036,0.000005686037,0.000009330183,0.00005603366,0.000007959816,0.0006321468,0.997058,0.00001866545,0.0006127848,0.000003474393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818262,0.00201014,0.01288945,0.0002441136,0.0001618017,0.0001629159,0.0003067622,0.0004412076,0.001957398],"genre_scores_gemma":[0.9784439,0.001329737,0.01324726,0.0001463262,0.00002434336,0.0002199054,0.0002110369,0.00005777708,0.006319627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009332658,"threshold_uncertainty_score":0.003122091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006474399772852,"score_gpt":0.2491094746747234,"score_spread":0.2290447306769949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}