{"id":"W4205402118","doi":"10.1371/journal.ppat.1010183","title":"Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; Canada Research Chairs; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Antibody-dependent cell-mediated cytotoxicity; Monoclonal antibody; Antibody; Virology; Neutralizing antibody; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006320085,0.0008960987,0.0005049406,0.0005763683,0.000218647,0.00063746,0.0004866572,0.0008447249,0.001600155],"category_scores_gemma":[0.000268403,0.0004942463,0.0004071821,0.0001653118,0.0004875624,0.0005080308,0.0001902144,0.001862508,0.000380049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003914696,"about_ca_system_score_gemma":0.0003878847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007404291,"about_ca_topic_score_gemma":0.0007789168,"domain_scores_codex":[0.9995238,0.0001161236,0.00003451074,0.0001123589,0.00008676924,0.0001264629],"domain_scores_gemma":[0.9997948,0.00004425443,0.00005018488,0.00004752193,0.00001920252,0.00004414454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00162594,0.001392735,0.0001939482,0.00004572783,0.00002268715,0.00005466113,0.00005398651,0.0002204031,0.9929963,0.0001893529,0.0002063368,0.002997872],"study_design_scores_gemma":[0.0004656526,0.01940015,0.00362012,0.000022045,0.00007760491,0.0006438654,0.0000440914,0.002576439,0.9690888,0.0002170431,0.003828929,0.00001526711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993547,0.001371459,0.002392778,0.0002219523,0.00007807115,0.0001301265,0.0004903873,0.0001994406,0.001568698],"genre_scores_gemma":[0.9906327,0.001033048,0.002347393,0.000204509,0.00003830266,0.0001781267,0.000688639,0.00003971967,0.004837636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600155,"threshold_uncertainty_score":0.005353034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448916580348223,"score_gpt":0.2632087790161002,"score_spread":0.238719613212618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}