{"id":"W4205420497","doi":"10.3390/microorganisms10020198","title":"Proteomic Shifts Reflecting Oxidative Stress and Reduced Capacity for Protein Synthesis, and Alterations to Mitochondrial Membranes in Neurospora crassa Lacking VDAC","year":2022,"lang":"en","type":"article","venue":"Microorganisms","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences","keywords":"Neurospora crassa; Biochemistry; Voltage-dependent anion channel; Biology; Protein disulfide-isomerase; Endoplasmic reticulum; Mitochondrion; Thioredoxin; Methionine; Cell biology; Amino acid; Bacterial outer membrane; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008703797,0.0004515146,0.0002966577,0.0003413717,0.0002110222,0.0003562993,0.0002058641,0.0002780333,0.0005662949],"category_scores_gemma":[0.0001237229,0.0001962577,0.0003479215,0.0003429894,0.000283372,0.0002074435,0.0002395772,0.0004679438,0.0002364727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003568305,"about_ca_system_score_gemma":0.0002352843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003497348,"about_ca_topic_score_gemma":0.003297379,"domain_scores_codex":[0.9998919,0.000007487068,0.00001360953,0.00003601196,0.00002787105,0.00002311065],"domain_scores_gemma":[0.9998577,0.0000160851,0.00004638303,0.00001841215,0.00002405528,0.00003740351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000772252,0.000007678695,0.0005189876,0.00002497625,0.000006684428,0.0000792191,0.00001816571,0.00002356981,0.9989235,0.00001726055,0.00001531339,0.0002873714],"study_design_scores_gemma":[0.00001726253,0.0001865693,0.1054992,0.00001944595,0.0000784356,0.000977212,0.0003882412,0.0009060733,0.8887928,0.0001497145,0.002965067,0.00001995595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954543,0.0007773463,0.001086451,0.00007006674,0.00002379054,0.00001443783,0.001991211,0.0000458259,0.0005365913],"genre_scores_gemma":[0.9922454,0.0006697562,0.001908962,0.00008880714,0.000008952855,0.00003437916,0.003239063,0.00003999272,0.001764702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003497348,"threshold_uncertainty_score":0.006954014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329219182905587,"score_gpt":0.2666559708938691,"score_spread":0.2433637790648132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}