{"id":"W4205420497","doi":"10.3390/microorganisms10020198","title":"Proteomic Shifts Reflecting Oxidative Stress and Reduced Capacity for Protein Synthesis, and Alterations to Mitochondrial Membranes in Neurospora crassa Lacking VDAC","year":2022,"lang":"en","type":"article","venue":"Microorganisms","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences","keywords":"Neurospora crassa; Biochemistry; Voltage-dependent anion channel; Biology; Protein disulfide-isomerase; Endoplasmic reticulum; Mitochondrion; Thioredoxin; Methionine; Cell biology; Amino acid; Bacterial outer membrane; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775829,0.0001581301,0.0001801415,0.00008699358,0.0003369919,0.00005304348,0.0001030529,0.00008800231,0.00003191909],"category_scores_gemma":[0.0003142445,0.000173861,0.00003148029,0.0001178937,0.00004443158,0.000007699393,0.0001588954,0.0001503123,0.000001007802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002680936,"about_ca_system_score_gemma":0.00005717711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005248299,"about_ca_topic_score_gemma":0.0001731382,"domain_scores_codex":[0.9987574,0.000204444,0.0002205281,0.0005182381,0.00007056335,0.000228879],"domain_scores_gemma":[0.9996018,0.00002702892,0.00008286825,0.0001749276,0.00004216955,0.00007124346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002724774,0.00004290539,0.0002088021,0.00003651204,0.00001094434,0.00000285263,0.0005914079,0.00003706474,0.9983653,0.00006200006,0.0001248838,0.0002448338],"study_design_scores_gemma":[0.000604004,0.0003649673,0.000422484,0.00001763893,0.00001153281,0.00002674267,0.0002343878,0.00001095945,0.9946607,0.0001033318,0.003351942,0.0001912963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955428,0.00005219462,0.001929405,0.0005254869,0.0003055739,0.001447135,0.0001499174,0.00001532966,0.00003220497],"genre_scores_gemma":[0.9864657,0.000006314022,0.01189175,0.0003046158,0.000250249,0.0007552463,0.00007095972,0.00003334147,0.0002218286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009962346,"threshold_uncertainty_score":0.7089845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329219182905587,"score_gpt":0.2666559708938691,"score_spread":0.2433637790648132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}