{"id":"W4205462144","doi":"10.1111/cns.13789","title":"Results from a multicenter, randomized, double‐blind, placebo‐controlled study of repository corticotropin injection for multiple sclerosis relapse that did not adequately respond to corticosteroids","year":2022,"lang":"en","type":"article","venue":"CNS Neuroscience & Therapeutics","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Mallinckrodt Pharmaceuticals; Biogen","keywords":"Placebo; Multiple sclerosis; Medicine; Adverse effect; Adrenocorticotropic hormone; Expanded Disability Status Scale; Internal medicine; Randomized controlled trial; Placebo group; Clinical trial; Corticosteroid; Hormone; Immunology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001604489,0.0004588537,0.001600841,0.000580265,0.001089714,0.0001418699,0.0006780801,0.00008804403,0.000009154621],"category_scores_gemma":[0.002777713,0.0003806975,0.0004437454,0.0009084796,0.0005073781,0.0002159671,0.0006554025,0.0006097195,0.000003319028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282073,"about_ca_system_score_gemma":0.0002233957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005201111,"about_ca_topic_score_gemma":0.0001236524,"domain_scores_codex":[0.9930581,0.001239688,0.001638777,0.001316976,0.001962274,0.0007841235],"domain_scores_gemma":[0.9940203,0.003137161,0.0008416337,0.001206991,0.0004586484,0.0003352245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6122284,0.001966305,0.002560446,0.00001756469,0.0001885044,0.00001248632,0.005676079,0.001534013,0.3744794,0.000001664127,0.00004639176,0.00128877],"study_design_scores_gemma":[0.8730928,0.009492161,0.02714188,0.00009830922,0.0008524315,0.00001174369,0.005602221,0.04424587,0.03842708,0.000004130949,0.0006429384,0.0003883793],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804013,0.0001613645,0.0009052834,0.000919667,0.001609573,0.01558891,0.0002496305,0.0001217502,0.00004253525],"genre_scores_gemma":[0.9930488,0.0002187799,0.0003850518,0.001476305,0.0001153286,0.003945149,0.00002327108,0.00007455422,0.0007127099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3360523,"threshold_uncertainty_score":0.9998645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1973807040451979,"score_gpt":0.3520723779018734,"score_spread":0.1546916738566755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}