{"id":"W4205468246","doi":"10.21203/rs.3.rs-1175817/v1","title":"Stroke genetics informs drug discovery and risk prediction across ancestries","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; McGill University; Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"National Institute of Neurological Disorders and Stroke; Faculty of Medicine and Health, University of Sydney; Erasmus Universitair Medisch Centrum Rotterdam; Leids Universitair Medisch Centrum; Medical Research Council; Ohio State University; University of Tokyo; Agence Nationale de la Recherche; Universiteit Maastricht; Universiteit van Amsterdam; University of California, San Diego; Universiteit Leiden; University of Bristol; Statens Serum Institut; Center for Clinical and Translational Science, Ohio State University; Institut National de la Santé et de la Recherche Médicale; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Amsterdam University Medical Centers; Massachusetts General Hospital; University of Minnesota; Norges Teknisk-Naturvitenskapelige Universitet; Maastricht Universitair Medisch Centrum; University of Washington; Universitair Medisch Centrum Groningen; McKnight Foundation","keywords":"Drug discovery; Drug; Computational biology; Genetics; Computer science; Biology; Bioinformatics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002420174,0.0002392696,0.0002986092,0.00009912783,0.0006916642,0.0001762399,0.0003973897,0.0004281283,0.00003035696],"category_scores_gemma":[0.000899669,0.0002264,0.0001403172,0.0001296583,0.0003682117,0.000007227208,0.003300018,0.001233599,0.000004364649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001018358,"about_ca_system_score_gemma":0.0003915526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005161839,"about_ca_topic_score_gemma":0.000418456,"domain_scores_codex":[0.9970549,0.0006295631,0.0004113031,0.0007155904,0.0005047127,0.0006838768],"domain_scores_gemma":[0.9985046,0.000137542,0.0002277102,0.000730982,0.0002603449,0.0001388559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008467034,0.00006015418,0.9774448,0.0001594028,0.0002029559,0.000002799461,0.00053527,0.005221818,0.0007080938,0.00002618725,0.008949181,0.006604684],"study_design_scores_gemma":[0.0005937681,0.0006282535,0.8766626,0.00005056216,0.00003754057,0.000006496088,0.004758309,0.0009776953,0.001134461,0.001324075,0.1134267,0.0003995882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852356,0.007756481,0.0005682762,0.0002041157,0.0003572143,0.0005970785,0.004739271,0.00001866343,0.0005232965],"genre_scores_gemma":[0.9414023,0.05038289,0.0005516646,0.00002851862,0.0005232256,0.0003341741,0.002185426,0.00003563068,0.004556178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1044775,"threshold_uncertainty_score":0.9232326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03432576355668958,"score_gpt":0.3803038589028907,"score_spread":0.3459780953462011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}