{"id":"W4205468989","doi":"10.1007/s00262-021-03088-y","title":"Combination immunotherapy including OncoVEXmGMCSF creates a favorable tumor immune micro-environment in transgenic BRAF murine melanoma","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Cancer Institute; Fundação para a Ciência e a Tecnologia; U.S. Food and Drug Administration; Swim Across America","keywords":"Oncolytic virus; Medicine; Cancer research; Melanoma; Immunotherapy; Immune system; FOXP3; Cytotoxic T cell; Immune checkpoint; Tumor microenvironment; Combination therapy; CD8; Immunology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001370011,0.0007015746,0.001352708,0.001017743,0.0007473299,0.00006968954,0.000945118,0.0002370075,0.03773011],"category_scores_gemma":[0.00001976302,0.0007463843,0.0005099927,0.001113936,0.0005203885,0.0002671939,0.0002841925,0.001865821,0.00008768323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003773855,"about_ca_system_score_gemma":0.0006768121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002883187,"about_ca_topic_score_gemma":0.0000445961,"domain_scores_codex":[0.9947938,0.0007803362,0.001274719,0.001025175,0.0007875503,0.001338377],"domain_scores_gemma":[0.997724,0.0002619842,0.0004072736,0.001395407,0.0001055489,0.0001057896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008976177,0.001586708,0.01455565,0.0000498341,0.00125711,0.0001367651,0.002721684,0.0002358245,0.9079074,0.00009539736,0.0001191602,0.06235829],"study_design_scores_gemma":[0.05519603,0.007179626,0.1394258,0.0002674263,0.0001200955,0.0009019762,0.002735656,0.0003244723,0.531727,0.001097464,0.2594071,0.001617381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.89933,0.09249949,0.00008554717,0.003949047,0.0006848359,0.002204443,0.00006933718,0.0001800694,0.0009972405],"genre_scores_gemma":[0.9436567,0.03960151,0.0003338309,0.001671844,0.0001076418,0.002884238,0.0002240076,0.0003069502,0.0112133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3761804,"threshold_uncertainty_score":0.9994987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658907785339104,"score_gpt":0.3032453718668765,"score_spread":0.2766562940134855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}