{"id":"W4205476754","doi":"10.21203/rs.3.rs-1191837/v1","title":"SARS-CoV-2 Omicron spike mediated immune escape and tropism shift","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Strategic International Collaborative Research Program; Core Research for Evolutional Science and Technology; Research Institute for Microbial Diseases, Osaka University; Japan Society for the Promotion of Science; Institute of Genetics; Fast Grants; Engineering and Physical Sciences Research Council; UK Research and Innovation; Burroughs Wellcome Fund; European Association for the Study of the Liver; Rosetrees Trust; Tokyo Biochemical Research Foundation; Wellcome Trust; Bill and Melinda Gates Foundation; Japan Agency for Medical Research and Development; NHS Blood and Transplant; National Institute of Allergy and Infectious Diseases; Medical Research Council; Howard Hughes Medical Institute","keywords":"Viral entry; Biology; Tropism; Virology; Virus; Chemistry; Molecular biology; Cell biology; Viral replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903948,0.0003741869,0.0003135985,0.0002047725,0.0002073158,0.0006916503,0.0001722613,0.0005912328,0.007643454],"category_scores_gemma":[0.0003310819,0.0001442607,0.0003737372,0.0001078374,0.0002550684,0.0003810496,0.0005882852,0.0008256996,0.001395639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004604013,"about_ca_system_score_gemma":0.0002858036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004884192,"about_ca_topic_score_gemma":0.0003664597,"domain_scores_codex":[0.9997813,0.00003474183,0.000006408562,0.00003685355,0.00004730005,0.00009333767],"domain_scores_gemma":[0.9998988,0.00001992856,0.00002118992,0.00001506135,0.00001423172,0.00003076662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005798885,0.0001047564,0.002713452,0.00007029405,0.00002201298,0.0004683053,0.00007722521,0.001015104,0.9782379,0.006976933,0.001798446,0.007935621],"study_design_scores_gemma":[0.000308061,0.001693816,0.09173188,0.00006494909,0.0000764813,0.004434783,0.001023726,0.04381158,0.7967427,0.02913023,0.03091595,0.00006587802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735097,0.001594881,0.00731673,0.00120628,0.0002664115,0.00004373821,0.000631774,0.0001390001,0.01529155],"genre_scores_gemma":[0.9908126,0.0003417454,0.001362851,0.0002976072,0.00005197844,0.00001637762,0.0004362653,0.00003419209,0.006646401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007643454,"threshold_uncertainty_score":0.02556992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08345382379063893,"score_gpt":0.4247988936333139,"score_spread":0.341345069842675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}