{"id":"W4205484767","doi":"10.1158/1078-0432.ccr-21-3261","title":"Anti-CD79B Antibody–Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Neutropenia; Lymphoma; Internal medicine; Adverse effect; Phases of clinical research; Diffuse large B-cell lymphoma; Rituximab; Nausea; Gastroenterology; Pharmacokinetics; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024834,0.0008585929,0.001335298,0.0003186041,0.0002360861,0.0005159729,0.0004842313,0.0005979848,0.001245181],"category_scores_gemma":[0.0006160805,0.0003706439,0.0005860254,0.0002776495,0.0004956945,0.0004741783,0.0002477326,0.001519615,0.0004435179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007261369,"about_ca_system_score_gemma":0.0007937786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005625855,"about_ca_topic_score_gemma":0.00109586,"domain_scores_codex":[0.9996697,0.0001425042,0.00002018751,0.0000509636,0.00005011614,0.00006651802],"domain_scores_gemma":[0.9996495,0.00006792434,0.00007530063,0.00003311991,0.00003036108,0.0001436755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.292213,0.1459602,0.06768222,0.001300496,0.002343087,0.000787248,0.001130998,0.006746649,0.1262064,0.000326693,0.004217518,0.3510855],"study_design_scores_gemma":[0.2445717,0.6785772,0.05808839,0.00005112101,0.0005843218,0.0008019781,0.00009801421,0.002807346,0.01018591,0.0001698401,0.004028152,0.0000360011],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983475,0.0007118036,0.0001159095,0.0000832045,0.00001264457,0.0003023706,0.00009182991,0.00002070369,0.0003139057],"genre_scores_gemma":[0.9971985,0.0006407814,0.000558866,0.0002921279,0.00004218728,0.0003528406,0.0004145858,0.000007625594,0.0004925141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335298,"threshold_uncertainty_score":0.00541985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111040478869582,"score_gpt":0.516506773739555,"score_spread":0.405466294869973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}