{"id":"W4205484767","doi":"10.1158/1078-0432.ccr-21-3261","title":"Anti-CD79B Antibody–Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Neutropenia; Lymphoma; Internal medicine; Adverse effect; Phases of clinical research; Diffuse large B-cell lymphoma; Rituximab; Nausea; Gastroenterology; Pharmacokinetics; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.008992269,0.0002956557,0.0009380728,0.0007069064,0.0004669378,0.0000869693,0.0006226296,0.000115619,0.006016561],"category_scores_gemma":[0.0003650695,0.0002507533,0.0001820203,0.002342799,0.0005321206,0.0001627679,0.0007502376,0.0022908,0.0001077747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009780086,"about_ca_system_score_gemma":0.001620691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002569165,"about_ca_topic_score_gemma":0.000300446,"domain_scores_codex":[0.9905149,0.002272381,0.001125175,0.001201437,0.003704524,0.001181612],"domain_scores_gemma":[0.9961572,0.001201748,0.0001720489,0.001088611,0.0008281203,0.0005522558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02047297,0.02470724,0.9140695,0.00009290611,0.0001394708,0.0003531364,0.0006761297,0.00006437748,0.002865102,0.000003143101,0.002640448,0.03391561],"study_design_scores_gemma":[0.08180325,0.01328376,0.891228,0.00008893358,0.00005112049,0.000003087658,0.001030151,0.0008780451,0.0005919187,0.00002003414,0.0107148,0.0003069425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919443,0.0002270554,0.000005829373,0.0009643079,0.0003144443,0.004636184,0.0000799618,0.00004936455,0.001778619],"genre_scores_gemma":[0.9931849,0.0002152877,0.00003277567,0.0002819292,0.0003555292,0.0006806157,0.0001728238,0.0001094069,0.004966764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06133028,"threshold_uncertainty_score":0.9999945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111040478869582,"score_gpt":0.516506773739555,"score_spread":0.405466294869973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}