{"id":"W4205488419","doi":"10.3390/cancers14020353","title":"CDK5RAP3, a New BRCA2 Partner That Regulates DNA Repair, Is Associated with Breast Cancer Survival","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Ministero dello Sviluppo Economico; Institució Catalana de Recerca i Estudis Avançats; Cancer Research UK; Government of Canada; Centres de Recerca de Catalunya; Fondation du cancer du sein du Québec; Ministerio de Ciencia, Innovación y Universidades; European Commission; Breast Cancer Research Foundation; Fanconi Anemia Research Fund; Generalitat de Catalunya; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Agencia Estatal de Investigación; Genome Canada; National Institutes of Health; Ovarian Cancer Research Fund","keywords":"Genome instability; Homologous recombination; DNA repair; Breast cancer; DNA damage; BRCA2 Protein; Biology; Cancer research; Ovarian cancer; DNA; Genetics; Mutation; Cancer; Germline mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000869342,0.000268953,0.000196628,0.0004177424,0.0001891596,0.0002772704,0.0001158739,0.0001627417,0.001583625],"category_scores_gemma":[0.0002023028,0.00007972575,0.000250757,0.0004426369,0.0001157881,0.00009768801,0.0001585766,0.0002319968,0.0003256522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000262501,"about_ca_system_score_gemma":0.0001532957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110117,"about_ca_topic_score_gemma":0.001076302,"domain_scores_codex":[0.9999322,0.000007918562,0.000005631807,0.00002329598,0.0000186812,0.00001226654],"domain_scores_gemma":[0.9998575,0.00001489922,0.00007896303,0.000009810697,0.00001290438,0.00002600534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001345954,0.00003901553,0.1143864,0.0002621887,0.0002342415,0.001652507,0.00007426235,0.0006391073,0.8477648,0.000556656,0.0009471941,0.03209762],"study_design_scores_gemma":[0.00003556899,0.0002013369,0.7538256,0.00004387031,0.0002587487,0.01024491,0.0001032294,0.002736126,0.2185735,0.000839948,0.01310862,0.00002866071],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803056,0.01194541,0.003506592,0.0001514438,0.00003337278,0.00001121458,0.002577624,0.0001432907,0.0013254],"genre_scores_gemma":[0.9961468,0.001062319,0.0008475478,0.00004077143,0.000009539438,0.000004230024,0.0009991813,0.00001399353,0.0008757183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583625,"threshold_uncertainty_score":0.00529778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793874333845275,"score_gpt":0.2504913638523438,"score_spread":0.232552620513891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}