{"id":"W4205491929","doi":"10.1016/j.ccell.2021.12.009","title":"MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells","year":2022,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Université de Montréal","funders":"Ipsen; Conseil régional de Bourgogne-Franche-Comté; Ligue Contre le Cancer; Division of Agriculture and Natural Resources, University of California; Servier; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Sanofi; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Roche; Novartis; Association pour la Recherche sur le Cancer; Amgen; Pfizer; Université de Bourgogne; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Chemoimmunotherapy; Cancer research; Mitophagy; CXCL10; Autophagy; Medicine; Nivolumab; Immunotherapy; Immunology; Immune system; Chemistry; Chemokine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002766208,0.0002278042,0.0003533506,0.0001011209,0.0001790866,0.00002280883,0.0001332981,0.00008226022,0.006753781],"category_scores_gemma":[0.000002529202,0.0002367621,0.0001294974,0.0005287832,0.00007207099,0.0001337211,0.00004972638,0.0004010244,0.000004912029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0021929,"about_ca_system_score_gemma":0.000374789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006065031,"about_ca_topic_score_gemma":0.001434429,"domain_scores_codex":[0.9982946,0.00007380032,0.000385193,0.0004468047,0.0003993177,0.0004002759],"domain_scores_gemma":[0.9993389,0.00003758145,0.0001743601,0.000337207,0.00004202126,0.00006991565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002278747,0.0002469307,0.002151318,0.0001434306,0.00005921963,0.0000236787,0.00156435,0.00006284673,0.9238746,0.000006252299,0.06222677,0.007361891],"study_design_scores_gemma":[0.006026729,0.0001522938,0.002932617,0.0002007001,0.00003417526,0.000003739174,0.0008864057,0.00002978643,0.5757174,0.00002915436,0.4136428,0.0003442497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9142961,0.07687858,0.00001270265,0.001987393,0.0008431111,0.0005735789,0.0002136558,0.0000635095,0.005131355],"genre_scores_gemma":[0.9633467,0.01372294,0.00008186143,0.005396676,0.0001618469,0.0007563963,0.00006686493,0.00007220434,0.01639456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.351416,"threshold_uncertainty_score":0.9941542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357341629019067,"score_gpt":0.2701033484285613,"score_spread":0.2565299321383706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}