{"id":"W4205491929","doi":"10.1016/j.ccell.2021.12.009","title":"MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells","year":2022,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Université de Montréal","funders":"Ipsen; Conseil régional de Bourgogne-Franche-Comté; Ligue Contre le Cancer; Division of Agriculture and Natural Resources, University of California; Servier; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Sanofi; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Roche; Novartis; Association pour la Recherche sur le Cancer; Amgen; Pfizer; Université de Bourgogne; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Chemoimmunotherapy; Cancer research; Mitophagy; CXCL10; Autophagy; Medicine; Nivolumab; Immunotherapy; Immunology; Immune system; Chemistry; Chemokine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131319,0.000415573,0.0003384713,0.0002872446,0.0001928743,0.0004382479,0.0003356684,0.0002528483,0.003067936],"category_scores_gemma":[0.000110514,0.0001422382,0.000318904,0.0001480823,0.0001983627,0.0001871525,0.0002331123,0.001375844,0.0006456262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005497998,"about_ca_system_score_gemma":0.0005164244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002085621,"about_ca_topic_score_gemma":0.004542117,"domain_scores_codex":[0.9998092,0.0000222914,0.00001041011,0.00002457131,0.00003695087,0.00009663708],"domain_scores_gemma":[0.9999424,0.00001009267,0.000007055909,0.000009604503,0.00001036573,0.00002044107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001204995,0.0008951799,0.0007463803,0.0001971807,0.0000429774,0.0001111342,0.0000595969,0.0008934792,0.9670895,0.000787895,0.003070191,0.02490143],"study_design_scores_gemma":[0.0001949805,0.001768378,0.003657006,0.00001388543,0.00005279077,0.000335408,0.00005679166,0.003006155,0.9769648,0.0001192363,0.01381865,0.00001183722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872193,0.001701629,0.002002614,0.000561582,0.0002730641,0.0001318461,0.0008302408,0.0005155399,0.006764177],"genre_scores_gemma":[0.9927408,0.0006080079,0.001102685,0.00009851729,0.00001904632,0.00006326488,0.0005781547,0.00002639135,0.004763076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003067936,"threshold_uncertainty_score":0.01026326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357341629019067,"score_gpt":0.2701033484285613,"score_spread":0.2565299321383706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}