{"id":"W4205492763","doi":"10.1002/9780470015902.a0029375","title":"Li–Fraumeni Syndrome","year":2021,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Li–Fraumeni syndrome; Cancer; Germline; Germline mutation; Cancer research; Cancer syndrome; DNA repair; Breast cancer; Biology; DNA damage; Mutation; Medicine; Gene; Oncology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007602588,0.0007641784,0.0003386624,0.001371085,0.0004801139,0.0003717343,0.0002541419,0.0006453555,0.02459802],"category_scores_gemma":[0.0004772925,0.00008090774,0.000256076,0.0009172007,0.0002810066,0.000346767,0.0003246605,0.0004990991,0.0045403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780514,"about_ca_system_score_gemma":0.0003395083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001831608,"about_ca_topic_score_gemma":0.001630596,"domain_scores_codex":[0.9999119,0.000009124982,0.000007220969,0.00002054147,0.00002630554,0.00002476005],"domain_scores_gemma":[0.9998912,0.00002657935,0.00002502757,0.000006795368,0.00001546001,0.00003495956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005303209,0.0001545749,0.03757467,0.00117809,0.000122092,0.4054607,0.0004700335,0.000640203,0.0323168,0.02418647,0.08835595,0.4090101],"study_design_scores_gemma":[0.00004556037,0.00007463535,0.01699811,0.000492375,0.00008523421,0.6562572,0.0001362752,0.0003180132,0.006350806,0.006431796,0.3127697,0.00004026898],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.3289063,0.1829589,0.01336395,0.01193375,0.002433497,0.0003155136,0.009205773,0.002289893,0.4485925],"genre_scores_gemma":[0.7258402,0.03630604,0.005540986,0.002296457,0.0006355573,0.00009909143,0.004219333,0.0001692682,0.2248932],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.02459802,"threshold_uncertainty_score":0.08228862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765674195779985,"score_gpt":0.2748445794189551,"score_spread":0.2571878374611553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}